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Classification of Exudative Age-Related Macular Degeneration With Pachyvessels on En Face Swept-Source Optical Coherence Tomography.

Publication ,  Journal Article
Ng, DS-C; Bakthavatsalam, M; Lai, FH-P; Cheung, CY-L; Cheung, GC-M; Tang, FY; Tsang, CW; Lai, TY-Y; Wong, TY; Brelén, ME
Published in: Invest Ophthalmol Vis Sci
February 1, 2017

PURPOSE: The purpose of this study was to classify exudative maculopathy by the presence of pachyvessels on en face swept-source optical coherence tomography (SSOCT). METHODS: Consecutive patients with signs of exudative maculopathy underwent SSOCT, fluorescein and indocyanine green angiography (ICGA), ultra-widefield fundus color photography, and autofluorescence examinations. Images were analyzed in a masked fashion by two sets of four examiners in different sessions: (1) the presence of pachyvessels in en face OCT and (2) features of exudative maculopathy in conventional imaging modalities. Quantitative data obtained were subfoveal choroidal thickness (SFCT) and choroidal vascularity index (CVI), which was the ratio of choroidal vessels lumen area to a specified choroidal area from binarized cross-sectional OCT scans. RESULTS: Pachyvessels was observed in 38 (52.1%) of 73 eyes. The pachyvessels group was associated with younger age (69.1 ± 9.4 years, odds ratio [OR] = 0.95, 95% confidence interval [95% CI] = 0.90-0.97, P = 0.04), presence of polypoidal lesions (OR = 3.27, 95% CI = 1.24-8.62, P = 0.01), increased SFCT (OR = 1.08, 95% CI = 1.02-1.14, P < 0.01), and increased CVI (65.4 ± 5.3, OR = 1.12, 95% CI = 1.02-1.23, P = 0.01). In multivariate regression, CVI significantly correlated with pachyvessels (OR = 1.24, 95% CI = 1.03-1.55, P = 0.04). CONCLUSIONS: Exudative maculopathy could be classified based on differences in choroidal vasculature morphology. Current results implied that choroidal hemodynamics may be relevant to variable natural history and treatment response in neovascular AMD and polypoidal choroidal vasculopathy.

Duke Scholars

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

February 1, 2017

Volume

58

Issue

2

Start / End Page

1054 / 1062

Location

United States

Related Subject Headings

  • Wet Macular Degeneration
  • Visual Acuity
  • Tomography, Optical Coherence
  • Retrospective Studies
  • Retinal Vessels
  • Retinal Pigment Epithelium
  • Reproducibility of Results
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
 

Citation

APA
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ICMJE
MLA
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Ng, D.-C., Bakthavatsalam, M., Lai, F.-P., Cheung, C.-L., Cheung, G.-M., Tang, F. Y., … Brelén, M. E. (2017). Classification of Exudative Age-Related Macular Degeneration With Pachyvessels on En Face Swept-Source Optical Coherence Tomography. Invest Ophthalmol Vis Sci, 58(2), 1054–1062. https://doi.org/10.1167/iovs.16-20519
Ng, Danny Siu-Chun, Malini Bakthavatsalam, Frank Hiu-Ping Lai, Carol Yim-Lui Cheung, Gemmy Chu-Ming Cheung, Fang Yao Tang, Chi Wai Tsang, Timothy Yuk-Yau Lai, Tien Yin Wong, and Mårten Erik Brelén. “Classification of Exudative Age-Related Macular Degeneration With Pachyvessels on En Face Swept-Source Optical Coherence Tomography.Invest Ophthalmol Vis Sci 58, no. 2 (February 1, 2017): 1054–62. https://doi.org/10.1167/iovs.16-20519.
Ng DS-C, Bakthavatsalam M, Lai FH-P, Cheung CY-L, Cheung GC-M, Tang FY, et al. Classification of Exudative Age-Related Macular Degeneration With Pachyvessels on En Face Swept-Source Optical Coherence Tomography. Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):1054–62.
Ng, Danny Siu-Chun, et al. “Classification of Exudative Age-Related Macular Degeneration With Pachyvessels on En Face Swept-Source Optical Coherence Tomography.Invest Ophthalmol Vis Sci, vol. 58, no. 2, Feb. 2017, pp. 1054–62. Pubmed, doi:10.1167/iovs.16-20519.
Ng DS-C, Bakthavatsalam M, Lai FH-P, Cheung CY-L, Cheung GC-M, Tang FY, Tsang CW, Lai TY-Y, Wong TY, Brelén ME. Classification of Exudative Age-Related Macular Degeneration With Pachyvessels on En Face Swept-Source Optical Coherence Tomography. Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):1054–1062.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

February 1, 2017

Volume

58

Issue

2

Start / End Page

1054 / 1062

Location

United States

Related Subject Headings

  • Wet Macular Degeneration
  • Visual Acuity
  • Tomography, Optical Coherence
  • Retrospective Studies
  • Retinal Vessels
  • Retinal Pigment Epithelium
  • Reproducibility of Results
  • Ophthalmology & Optometry
  • Middle Aged
  • Male