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Association of neuropsychiatric symptoms and sub-syndromes with cognitive impairment in community-dwelling Asian elderly.

Publication ,  Journal Article
Xu, X; Ang, SL; Hilal, S; Chan, QL; Wong, TY; Venketasubramanian, N; Ikram, MK; Chen, CL-H
Published in: Int Psychogeriatr
November 2015

OBJECTIVES: To investigate the presence of neuropsychiatric symptoms (NPS) and sub-syndromes in elderly community-dwelling Asians with varying severity of cognitive impairment. METHODS: Chinese and Malay participants (n = 613) from the Epidemiology of Dementia in Singapore (EDIS) Study aged ≥ 60 years underwent clinical examination, neuropsychological testing, and NPS assessment using the Neuropsychiatric Inventory (NPI). Diagnosis of no cognitive impairment (NCI), cognitive impairment-no dementia (CIND), including CIND-mild and CIND-moderate, and dementia were made using established criteria. RESULTS: A significant increase in the numbers of NPS was observed accompanying with increasing severity of cognitive impairment (p < 0.001). Compared to those with NCI/CIND-mild, participants with CIND-moderate [Odds ratio (OR): 4.2, 95% confidence interval (CI): 1.8-10.0] or dementia [OR: 9.2, 95% CI: 2.3-36.0] were more likely to have two or more neuropsychiatric sub-syndromes. Participants with CIND-moderate were more likely to have hyperactivity [OR: 2.0, 95% CI: 1.0-3.8] and apathy [OR: 2.9, 95% CI: 1.0-8.4] sub-syndromes, whereas patients with dementia were more likely to have psychosis [OR: 6.9, 95% CI: 2.4-20.1], affective (OR: 8.7, 95% CI: 1.8-42.9), and hyperactivity (OR: 5.4, 95% CI: 1.8-16.1). Furthermore, executive dysfunction and visual memory impairment were associated with the presence of three neuropsychiatric sub-syndromes; whist language and visuomotor speed impairment were related to the presence of two sub-syndromes. By contrast, impairment in attention, verbal memory, and visuoconstruction were not associated with any of the sub-syndromes. CONCLUSIONS: The presence of NPS and sub-syndromes increase with increasing severities of cognitive impairment, and different neuropsychiatric syndromes are associated with specific impairment on cognitive domains in community-dwelling Asian elderly.

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Published In

Int Psychogeriatr

DOI

EISSN

1741-203X

Publication Date

November 2015

Volume

27

Issue

11

Start / End Page

1839 / 1847

Location

England

Related Subject Headings

  • Syndrome
  • Singapore
  • Psychotic Disorders
  • Psychomotor Agitation
  • Neuropsychological Tests
  • Middle Aged
  • Memory Disorders
  • Male
  • Independent Living
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Xu, X., Ang, S. L., Hilal, S., Chan, Q. L., Wong, T. Y., Venketasubramanian, N., … Chen, C.-H. (2015). Association of neuropsychiatric symptoms and sub-syndromes with cognitive impairment in community-dwelling Asian elderly. Int Psychogeriatr, 27(11), 1839–1847. https://doi.org/10.1017/S1041610215000976
Xu, Xin, Seow Li Ang, Saima Hilal, Qun Lin Chan, Tien Yin Wong, Narayanaswamy Venketasubramanian, Mohammad Kamran Ikram, and Christopher Li-Hsian Chen. “Association of neuropsychiatric symptoms and sub-syndromes with cognitive impairment in community-dwelling Asian elderly.Int Psychogeriatr 27, no. 11 (November 2015): 1839–47. https://doi.org/10.1017/S1041610215000976.
Xu X, Ang SL, Hilal S, Chan QL, Wong TY, Venketasubramanian N, et al. Association of neuropsychiatric symptoms and sub-syndromes with cognitive impairment in community-dwelling Asian elderly. Int Psychogeriatr. 2015 Nov;27(11):1839–47.
Xu, Xin, et al. “Association of neuropsychiatric symptoms and sub-syndromes with cognitive impairment in community-dwelling Asian elderly.Int Psychogeriatr, vol. 27, no. 11, Nov. 2015, pp. 1839–47. Pubmed, doi:10.1017/S1041610215000976.
Xu X, Ang SL, Hilal S, Chan QL, Wong TY, Venketasubramanian N, Ikram MK, Chen CL-H. Association of neuropsychiatric symptoms and sub-syndromes with cognitive impairment in community-dwelling Asian elderly. Int Psychogeriatr. 2015 Nov;27(11):1839–1847.
Journal cover image

Published In

Int Psychogeriatr

DOI

EISSN

1741-203X

Publication Date

November 2015

Volume

27

Issue

11

Start / End Page

1839 / 1847

Location

England

Related Subject Headings

  • Syndrome
  • Singapore
  • Psychotic Disorders
  • Psychomotor Agitation
  • Neuropsychological Tests
  • Middle Aged
  • Memory Disorders
  • Male
  • Independent Living
  • Humans