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A long-range flexible billboard model of gene activation.

Publication ,  Journal Article
Vockley, CM; McDowell, IC; D'Ippolito, AM; Reddy, TE
Published in: Transcription
August 8, 2017

Gene regulation is fundamentally important for the coordination of diverse biologic processes including homeostasis and responses to developmental and environmental stimuli. Transcription factor (TF) binding sites are one of the major functional subunits of gene regulation. They are arranged in cis-regulatory modules (CRMs) that can be more active than the sum of their individual effects. Recently, we described a mechanism of glucocorticoid (GC)-induced gene regulation in which the glucocorticoid receptor (GR) binds coordinately to multiple CRMs that are 10s of kilobases apart in the genome. In those results, the minority of GR binding sites appear to involve direct TF:DNA interactions. Meanwhile, other GR binding sites in a cluster interact with those direct binding sites to tune their gene regulatory activity. Here, we consider the implications of those and related results in the context of existing models of gene regulation. Based on our analyses, we propose that the billboard and regulatory grammar models of cis-regulatory element activity be expanded to consider the influence of long-range interactions between cis-regulatory modules.

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Published In

Transcription

DOI

EISSN

2154-1272

Publication Date

August 8, 2017

Volume

8

Issue

4

Start / End Page

261 / 267

Location

United States

Related Subject Headings

  • Transcriptional Activation
  • Regulon
  • Receptors, Glucocorticoid
  • Models, Genetic
  • DNA
  • Binding Sites
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
 

Citation

APA
Chicago
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MLA
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Vockley, C. M., McDowell, I. C., D’Ippolito, A. M., & Reddy, T. E. (2017). A long-range flexible billboard model of gene activation. Transcription, 8(4), 261–267. https://doi.org/10.1080/21541264.2017.1317694
Vockley, Christopher M., Ian C. McDowell, Antony M. D’Ippolito, and Timothy E. Reddy. “A long-range flexible billboard model of gene activation.Transcription 8, no. 4 (August 8, 2017): 261–67. https://doi.org/10.1080/21541264.2017.1317694.
Vockley CM, McDowell IC, D’Ippolito AM, Reddy TE. A long-range flexible billboard model of gene activation. Transcription. 2017 Aug 8;8(4):261–7.
Vockley, Christopher M., et al. “A long-range flexible billboard model of gene activation.Transcription, vol. 8, no. 4, Aug. 2017, pp. 261–67. Pubmed, doi:10.1080/21541264.2017.1317694.
Vockley CM, McDowell IC, D’Ippolito AM, Reddy TE. A long-range flexible billboard model of gene activation. Transcription. 2017 Aug 8;8(4):261–267.

Published In

Transcription

DOI

EISSN

2154-1272

Publication Date

August 8, 2017

Volume

8

Issue

4

Start / End Page

261 / 267

Location

United States

Related Subject Headings

  • Transcriptional Activation
  • Regulon
  • Receptors, Glucocorticoid
  • Models, Genetic
  • DNA
  • Binding Sites
  • 3105 Genetics
  • 3101 Biochemistry and cell biology