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Plasma lipoprotein subfraction concentrations are associated with lipid metabolism and age-related macular degeneration.

Publication ,  Journal Article
Cheung, CMG; Gan, A; Fan, Q; Chee, ML; Apte, RS; Khor, CC; Yeo, I; Mathur, R; Cheng, C-Y; Wong, TY; Tai, ES
Published in: J Lipid Res
September 2017

Disturbance in lipid metabolism has been suggested as a major pathogenic factor for age-related macular degeneration (AMD). Conventional lipid measures have been inconsistently associated with AMD. Other factors that can alter lipid metabolism include lipoprotein phenotype and genetic mutations. We performed a case-control study to examine the association between lipoprotein profile and neovascular AMD (nAMD) and whether the cholesterylester transfer protein (CETP) D442G mutation modulates these associations. Patients with nAMD had significantly higher concentrations of HDL and IDL compared with controls. The increase in HDL particles in nAMD patients was driven by an excess of medium-sized particles. Concurrently, patients with nAMD also had lower Apo A-1, lower VLDL and chylomicron lipoprotein. Many of these associations showed a dose-dependent association between controls, early AMD cases, and nAMD cases. Adjustment for the presence of the D442G mutation at the CETP locus did not significantly alter the increased AMD risk associated with HDL particle concentration. AMD is associated with variation in many lipoprotein subclasses, including increased HDL and IDL particles and decreased Apo A-1, VLDL, and chylomicron particles. These data suggest widespread systemic disturbance in lipid metabolism in the pathogenesis of AMD, including possible alterations in lipoprotein carrier capacity.

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Published In

J Lipid Res

DOI

EISSN

1539-7262

Publication Date

September 2017

Volume

58

Issue

9

Start / End Page

1785 / 1796

Location

United States

Related Subject Headings

  • Polymorphism, Genetic
  • Phenotype
  • Male
  • Macular Degeneration
  • Lipoproteins
  • Humans
  • Female
  • Cholesterol Ester Transfer Proteins
  • Case-Control Studies
  • Biochemistry & Molecular Biology
 

Citation

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Cheung, C. M. G., Gan, A., Fan, Q., Chee, M. L., Apte, R. S., Khor, C. C., … Tai, E. S. (2017). Plasma lipoprotein subfraction concentrations are associated with lipid metabolism and age-related macular degeneration. J Lipid Res, 58(9), 1785–1796. https://doi.org/10.1194/jlr.M073684
Cheung, Chui Ming Gemmy, Alfred Gan, Qiao Fan, Miao Ling Chee, Rajendra S. Apte, Chiea Chuen Khor, Ian Yeo, et al. “Plasma lipoprotein subfraction concentrations are associated with lipid metabolism and age-related macular degeneration.J Lipid Res 58, no. 9 (September 2017): 1785–96. https://doi.org/10.1194/jlr.M073684.
Cheung CMG, Gan A, Fan Q, Chee ML, Apte RS, Khor CC, et al. Plasma lipoprotein subfraction concentrations are associated with lipid metabolism and age-related macular degeneration. J Lipid Res. 2017 Sep;58(9):1785–96.
Cheung, Chui Ming Gemmy, et al. “Plasma lipoprotein subfraction concentrations are associated with lipid metabolism and age-related macular degeneration.J Lipid Res, vol. 58, no. 9, Sept. 2017, pp. 1785–96. Pubmed, doi:10.1194/jlr.M073684.
Cheung CMG, Gan A, Fan Q, Chee ML, Apte RS, Khor CC, Yeo I, Mathur R, Cheng C-Y, Wong TY, Tai ES. Plasma lipoprotein subfraction concentrations are associated with lipid metabolism and age-related macular degeneration. J Lipid Res. 2017 Sep;58(9):1785–1796.

Published In

J Lipid Res

DOI

EISSN

1539-7262

Publication Date

September 2017

Volume

58

Issue

9

Start / End Page

1785 / 1796

Location

United States

Related Subject Headings

  • Polymorphism, Genetic
  • Phenotype
  • Male
  • Macular Degeneration
  • Lipoproteins
  • Humans
  • Female
  • Cholesterol Ester Transfer Proteins
  • Case-Control Studies
  • Biochemistry & Molecular Biology