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Stimulus dependence of local field potential spectra: experiment versus theory.

Publication ,  Journal Article
Barbieri, F; Mazzoni, A; Logothetis, NK; Panzeri, S; Brunel, N
Published in: J Neurosci
October 29, 2014

The local field potential (LFP) captures different neural processes, including integrative synaptic dynamics that cannot be observed by measuring only the spiking activity of small populations. Therefore, investigating how LFP power is modulated by external stimuli can offer important insights into sensory neural representations. However, gaining such insight requires developing data-driven computational models that can identify and disambiguate the neural contributions to the LFP. Here, we investigated how networks of excitatory and inhibitory integrate-and-fire neurons responding to time-dependent inputs can be used to interpret sensory modulations of LFP spectra. We computed analytically from such models the LFP spectra and the information that they convey about input and used these analytical expressions to fit the model to LFPs recorded in V1 of anesthetized macaques (Macaca mulatta) during the presentation of color movies. Our expressions explain 60%-98% of the variance of the LFP spectrum shape and its dependency upon movie scenes and we achieved this with realistic values for the best-fit parameters. In particular, synaptic best-fit parameters were compatible with experimental measurements and the predictions of firing rates, based only on the fit of LFP data, correlated with the multiunit spike rate recorded from the same location. Moreover, the parameters characterizing the input to the network across different movie scenes correlated with cross-scene changes of several image features. Our findings suggest that analytical descriptions of spiking neuron networks may become a crucial tool for the interpretation of field recordings.

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Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

October 29, 2014

Volume

34

Issue

44

Start / End Page

14589 / 14605

Location

United States

Related Subject Headings

  • Visual Cortex
  • Photic Stimulation
  • Neurons
  • Neurology & Neurosurgery
  • Nerve Net
  • Models, Neurological
  • Male
  • Macaca
  • Gamma Rhythm
  • Animals
 

Citation

APA
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Barbieri, F., Mazzoni, A., Logothetis, N. K., Panzeri, S., & Brunel, N. (2014). Stimulus dependence of local field potential spectra: experiment versus theory. J Neurosci, 34(44), 14589–14605. https://doi.org/10.1523/JNEUROSCI.5365-13.2014
Barbieri, Francesca, Alberto Mazzoni, Nikos K. Logothetis, Stefano Panzeri, and Nicolas Brunel. “Stimulus dependence of local field potential spectra: experiment versus theory.J Neurosci 34, no. 44 (October 29, 2014): 14589–605. https://doi.org/10.1523/JNEUROSCI.5365-13.2014.
Barbieri F, Mazzoni A, Logothetis NK, Panzeri S, Brunel N. Stimulus dependence of local field potential spectra: experiment versus theory. J Neurosci. 2014 Oct 29;34(44):14589–605.
Barbieri, Francesca, et al. “Stimulus dependence of local field potential spectra: experiment versus theory.J Neurosci, vol. 34, no. 44, Oct. 2014, pp. 14589–605. Pubmed, doi:10.1523/JNEUROSCI.5365-13.2014.
Barbieri F, Mazzoni A, Logothetis NK, Panzeri S, Brunel N. Stimulus dependence of local field potential spectra: experiment versus theory. J Neurosci. 2014 Oct 29;34(44):14589–14605.

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

October 29, 2014

Volume

34

Issue

44

Start / End Page

14589 / 14605

Location

United States

Related Subject Headings

  • Visual Cortex
  • Photic Stimulation
  • Neurons
  • Neurology & Neurosurgery
  • Nerve Net
  • Models, Neurological
  • Male
  • Macaca
  • Gamma Rhythm
  • Animals