On the distribution of firing rates in networks of cortical neurons.
The distribution of in vivo average firing rates within local cortical networks has been reported to be highly skewed and long tailed. The distribution of average single-cell inputs, conversely, is expected to be Gaussian by the central limit theorem. This raises the issue of how a skewed distribution of firing rates might result from a symmetric distribution of inputs. We argue that skewed rate distributions are a signature of the nonlinearity of the in vivo f-I curve. During in vivo conditions, ongoing synaptic activity produces significant fluctuations in the membrane potential of neurons, resulting in an expansive nonlinearity of the f-I curve for low and moderate inputs. Here, we investigate the effects of single-cell and network parameters on the shape of the f-I curve and, by extension, on the distribution of firing rates in randomly connected networks.
Duke Scholars
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Related Subject Headings
- Time Factors
- Normal Distribution
- Nonlinear Dynamics
- Neurons
- Neurology & Neurosurgery
- Neural Inhibition
- Nerve Net
- Models, Neurological
- Computer Simulation
- Cerebral Cortex
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Time Factors
- Normal Distribution
- Nonlinear Dynamics
- Neurons
- Neurology & Neurosurgery
- Neural Inhibition
- Nerve Net
- Models, Neurological
- Computer Simulation
- Cerebral Cortex