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On the distribution of firing rates in networks of cortical neurons.

Publication ,  Journal Article
Roxin, A; Brunel, N; Hansel, D; Mongillo, G; van Vreeswijk, C
Published in: J Neurosci
November 9, 2011

The distribution of in vivo average firing rates within local cortical networks has been reported to be highly skewed and long tailed. The distribution of average single-cell inputs, conversely, is expected to be Gaussian by the central limit theorem. This raises the issue of how a skewed distribution of firing rates might result from a symmetric distribution of inputs. We argue that skewed rate distributions are a signature of the nonlinearity of the in vivo f-I curve. During in vivo conditions, ongoing synaptic activity produces significant fluctuations in the membrane potential of neurons, resulting in an expansive nonlinearity of the f-I curve for low and moderate inputs. Here, we investigate the effects of single-cell and network parameters on the shape of the f-I curve and, by extension, on the distribution of firing rates in randomly connected networks.

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Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

November 9, 2011

Volume

31

Issue

45

Start / End Page

16217 / 16226

Location

United States

Related Subject Headings

  • Time Factors
  • Normal Distribution
  • Nonlinear Dynamics
  • Neurons
  • Neurology & Neurosurgery
  • Neural Inhibition
  • Nerve Net
  • Models, Neurological
  • Computer Simulation
  • Cerebral Cortex
 

Citation

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Roxin, A., Brunel, N., Hansel, D., Mongillo, G., & van Vreeswijk, C. (2011). On the distribution of firing rates in networks of cortical neurons. J Neurosci, 31(45), 16217–16226. https://doi.org/10.1523/JNEUROSCI.1677-11.2011
Roxin, Alex, Nicolas Brunel, David Hansel, Gianluigi Mongillo, and Carl van Vreeswijk. “On the distribution of firing rates in networks of cortical neurons.J Neurosci 31, no. 45 (November 9, 2011): 16217–26. https://doi.org/10.1523/JNEUROSCI.1677-11.2011.
Roxin A, Brunel N, Hansel D, Mongillo G, van Vreeswijk C. On the distribution of firing rates in networks of cortical neurons. J Neurosci. 2011 Nov 9;31(45):16217–26.
Roxin, Alex, et al. “On the distribution of firing rates in networks of cortical neurons.J Neurosci, vol. 31, no. 45, Nov. 2011, pp. 16217–26. Pubmed, doi:10.1523/JNEUROSCI.1677-11.2011.
Roxin A, Brunel N, Hansel D, Mongillo G, van Vreeswijk C. On the distribution of firing rates in networks of cortical neurons. J Neurosci. 2011 Nov 9;31(45):16217–16226.

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

November 9, 2011

Volume

31

Issue

45

Start / End Page

16217 / 16226

Location

United States

Related Subject Headings

  • Time Factors
  • Normal Distribution
  • Nonlinear Dynamics
  • Neurons
  • Neurology & Neurosurgery
  • Neural Inhibition
  • Nerve Net
  • Models, Neurological
  • Computer Simulation
  • Cerebral Cortex