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Effects of synaptic noise and filtering on the frequency response of spiking neurons.

Publication ,  Journal Article
Brunel, N; Chance, FS; Fourcaud, N; Abbott, LF
Published in: Phys Rev Lett
March 5, 2001

Noise can have a significant impact on the response dynamics of a nonlinear system. For neurons, the primary source of noise comes from background synaptic input activity. If this is approximated as white noise, the amplitude of the modulation of the firing rate in response to an input current oscillating at frequency omega decreases as 1/square root[omega] and lags the input by 45 degrees in phase. However, if filtering due to realistic synaptic dynamics is included, the firing rate is modulated by a finite amount even in the limit omega-->infinity and the phase lag is eliminated. Thus, through its effect on noise inputs, realistic synaptic dynamics can ensure unlagged neuronal responses to high-frequency inputs.

Duke Scholars

Published In

Phys Rev Lett

DOI

ISSN

0031-9007

Publication Date

March 5, 2001

Volume

86

Issue

10

Start / End Page

2186 / 2189

Location

United States

Related Subject Headings

  • Synaptic Transmission
  • Synapses
  • Neurons
  • Models, Neurological
  • Mathematical Computing
  • General Physics
  • Action Potentials
  • 51 Physical sciences
  • 49 Mathematical sciences
  • 40 Engineering
 

Citation

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Brunel, N., Chance, F. S., Fourcaud, N., & Abbott, L. F. (2001). Effects of synaptic noise and filtering on the frequency response of spiking neurons. Phys Rev Lett, 86(10), 2186–2189. https://doi.org/10.1103/PhysRevLett.86.2186
Brunel, N., F. S. Chance, N. Fourcaud, and L. F. Abbott. “Effects of synaptic noise and filtering on the frequency response of spiking neurons.Phys Rev Lett 86, no. 10 (March 5, 2001): 2186–89. https://doi.org/10.1103/PhysRevLett.86.2186.
Brunel N, Chance FS, Fourcaud N, Abbott LF. Effects of synaptic noise and filtering on the frequency response of spiking neurons. Phys Rev Lett. 2001 Mar 5;86(10):2186–9.
Brunel, N., et al. “Effects of synaptic noise and filtering on the frequency response of spiking neurons.Phys Rev Lett, vol. 86, no. 10, Mar. 2001, pp. 2186–89. Pubmed, doi:10.1103/PhysRevLett.86.2186.
Brunel N, Chance FS, Fourcaud N, Abbott LF. Effects of synaptic noise and filtering on the frequency response of spiking neurons. Phys Rev Lett. 2001 Mar 5;86(10):2186–2189.

Published In

Phys Rev Lett

DOI

ISSN

0031-9007

Publication Date

March 5, 2001

Volume

86

Issue

10

Start / End Page

2186 / 2189

Location

United States

Related Subject Headings

  • Synaptic Transmission
  • Synapses
  • Neurons
  • Models, Neurological
  • Mathematical Computing
  • General Physics
  • Action Potentials
  • 51 Physical sciences
  • 49 Mathematical sciences
  • 40 Engineering