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A genome-wide association study identified a novel genetic loci STON1-GTF2A1L/LHCGR/FSHR for bilaterality of neovascular age-related macular degeneration.

Publication ,  Journal Article
Kawashima-Kumagai, K; Yamashiro, K; Yoshikawa, M; Miyake, M; Ming, GCC; Fan, Q; Koh, JY; Saito, M; Sugahara-Kuroda, M; Oishi, M; Nakata, I ...
Published in: Sci Rep
August 3, 2017

Bilateral neovascular age-related macular degeneration (AMD) causes much more handicaps for patients than unilateral neovascular AMD. Although several AMD-susceptibility genes have been evaluated for their associations to bilaterality, genome-wide association study (GWAS) on bilaterality has been rarely reported. In the present study, we performed GWAS using neovascular AMD cases in East Asian. The discovery stage compared 581,252 single nucleotide polymorphisms (SNPs) between 803 unilateral and 321 bilateral Japanese cases but no SNP showed genome-wide significance, while SNPs at six regions showed P-value < 1.0 × 10-5, STON1-GTF2A1L/LHCGR/FSHR, PLXNA1, CTNNA3, ARMS2/HTRA1, LHFP, and FLJ38725. The first replication study for these six regions comparing 36 bilateral and 132 unilateral Japanese cases confirmed significant associations of rs4482537 (STON1-GTF2A1L/LHCGR/FSHR), rs2284665 (ARMS2/HTRA1), and rs8002574 (LHFP) to bilaterality. In the second replication study comparing 24 bilateral and 78 unilateral cases from Singapore, rs4482537 (STON1-GTF2A1L/LHCGR/FSHR) only showed significant association. Meta-analysis of discovery and replication studies confirmed genome-wide level significant association (P = 2.61 × 10-9) of rs4482537 (STON1-GTF2A1L/LHCGR/FSHR) and strong associations (P = 5.76 × 10-7 and 9.73 × 10-7, respectively) of rs2284665 (ARMS2/HTRA1) and rs8002574 (LHFP). Our GWAS for neovascular AMD bilaterality found new genetic loci STON1-GTF2A1L/LHCGR/FSHR and confirmed the previously reported association of ARMS2/HTRA1.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

August 3, 2017

Volume

7

Issue

1

Start / End Page

7173

Location

England

Related Subject Headings

  • Wet Macular Degeneration
  • Polymorphism, Single Nucleotide
  • Neovascularization, Pathologic
  • Male
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Female
  • Case-Control Studies
  • Asian People
 

Citation

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Kawashima-Kumagai, K., Yamashiro, K., Yoshikawa, M., Miyake, M., Ming, G. C. C., Fan, Q., … Yoshimura, N. (2017). A genome-wide association study identified a novel genetic loci STON1-GTF2A1L/LHCGR/FSHR for bilaterality of neovascular age-related macular degeneration. Sci Rep, 7(1), 7173. https://doi.org/10.1038/s41598-017-07526-9
Kawashima-Kumagai, Kyoko, Kenji Yamashiro, Munemitsu Yoshikawa, Masahiro Miyake, Gemmy Cheung Chui Ming, Qiao Fan, Jia Yu Koh, et al. “A genome-wide association study identified a novel genetic loci STON1-GTF2A1L/LHCGR/FSHR for bilaterality of neovascular age-related macular degeneration.Sci Rep 7, no. 1 (August 3, 2017): 7173. https://doi.org/10.1038/s41598-017-07526-9.
Kawashima-Kumagai K, Yamashiro K, Yoshikawa M, Miyake M, Ming GCC, Fan Q, et al. A genome-wide association study identified a novel genetic loci STON1-GTF2A1L/LHCGR/FSHR for bilaterality of neovascular age-related macular degeneration. Sci Rep. 2017 Aug 3;7(1):7173.
Kawashima-Kumagai, Kyoko, et al. “A genome-wide association study identified a novel genetic loci STON1-GTF2A1L/LHCGR/FSHR for bilaterality of neovascular age-related macular degeneration.Sci Rep, vol. 7, no. 1, Aug. 2017, p. 7173. Pubmed, doi:10.1038/s41598-017-07526-9.
Kawashima-Kumagai K, Yamashiro K, Yoshikawa M, Miyake M, Ming GCC, Fan Q, Koh JY, Saito M, Sugahara-Kuroda M, Oishi M, Akagi-Kurashige Y, Nakata I, Nakanishi H, Gotoh N, Oishi A, Tamura H, Ooto S, Tsujikawa A, Kurimoto Y, Sekiryu T, Matsuda F, Khor C-C, Cheng C-Y, Wong TY, Yoshimura N. A genome-wide association study identified a novel genetic loci STON1-GTF2A1L/LHCGR/FSHR for bilaterality of neovascular age-related macular degeneration. Sci Rep. 2017 Aug 3;7(1):7173.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

August 3, 2017

Volume

7

Issue

1

Start / End Page

7173

Location

England

Related Subject Headings

  • Wet Macular Degeneration
  • Polymorphism, Single Nucleotide
  • Neovascularization, Pathologic
  • Male
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Female
  • Case-Control Studies
  • Asian People