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Comparing oncologic outcomes after minimally invasive and open surgery for pediatric neuroblastoma and Wilms tumor.

Publication ,  Journal Article
Ezekian, B; Englum, BR; Gulack, BC; Rialon, KL; Kim, J; Talbot, LJ; Adibe, OO; Routh, JC; Tracy, ET; Rice, HE
Published in: Pediatr Blood Cancer
January 2018

BACKGROUND: Minimally invasive surgery (MIS) has been widely adopted for common operations in pediatric surgery; however, its role in childhood tumors is limited by concerns about oncologic outcomes. We compared open and MIS approaches for pediatric neuroblastoma and Wilms tumor (WT) using a national database. METHODS: The National Cancer Data Base from 2010 to 2012 was queried for cases of neuroblastoma and WT in children ≤21 years old. Children were classified as receiving open or MIS surgery for definitive resection, with clinical outcomes compared using a propensity matching methodology (two open:one MIS). RESULTS: For children with neuroblastoma, 17% (98 of 579) underwent MIS, while only 5% of children with WT (35 of 695) had an MIS approach for tumor resection. After propensity matching, there was no difference between open and MIS surgery for either tumor for 30-day mortality, readmissions, surgical margin status, and 1- and 3-year survival. However, in both tumors, open surgery more often evaluated lymph nodes and had larger lymph node harvest. CONCLUSION: Our retrospective review suggests that the use of MIS appears to be a safe method of oncologic resection for select children with neuroblastoma and WT. Further research should clarify which children are the optimal candidates for this approach.

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Published In

Pediatr Blood Cancer

DOI

EISSN

1545-5017

Publication Date

January 2018

Volume

65

Issue

1

Location

United States

Related Subject Headings

  • Wilms Tumor
  • Retrospective Studies
  • Registries
  • Oncology & Carcinogenesis
  • Neuroblastoma
  • Minimally Invasive Surgical Procedures
  • Male
  • Kidney Neoplasms
  • Infant, Newborn
  • Infant
 

Citation

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MLA
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Ezekian, B., Englum, B. R., Gulack, B. C., Rialon, K. L., Kim, J., Talbot, L. J., … Rice, H. E. (2018). Comparing oncologic outcomes after minimally invasive and open surgery for pediatric neuroblastoma and Wilms tumor. Pediatr Blood Cancer, 65(1). https://doi.org/10.1002/pbc.26755
Ezekian, Brian, Brian R. Englum, Brian C. Gulack, Kristy L. Rialon, Jina Kim, Lindsay J. Talbot, Obinna O. Adibe, Jonathan C. Routh, Elisabeth T. Tracy, and Henry E. Rice. “Comparing oncologic outcomes after minimally invasive and open surgery for pediatric neuroblastoma and Wilms tumor.Pediatr Blood Cancer 65, no. 1 (January 2018). https://doi.org/10.1002/pbc.26755.
Ezekian B, Englum BR, Gulack BC, Rialon KL, Kim J, Talbot LJ, et al. Comparing oncologic outcomes after minimally invasive and open surgery for pediatric neuroblastoma and Wilms tumor. Pediatr Blood Cancer. 2018 Jan;65(1).
Ezekian, Brian, et al. “Comparing oncologic outcomes after minimally invasive and open surgery for pediatric neuroblastoma and Wilms tumor.Pediatr Blood Cancer, vol. 65, no. 1, Jan. 2018. Pubmed, doi:10.1002/pbc.26755.
Ezekian B, Englum BR, Gulack BC, Rialon KL, Kim J, Talbot LJ, Adibe OO, Routh JC, Tracy ET, Rice HE. Comparing oncologic outcomes after minimally invasive and open surgery for pediatric neuroblastoma and Wilms tumor. Pediatr Blood Cancer. 2018 Jan;65(1).
Journal cover image

Published In

Pediatr Blood Cancer

DOI

EISSN

1545-5017

Publication Date

January 2018

Volume

65

Issue

1

Location

United States

Related Subject Headings

  • Wilms Tumor
  • Retrospective Studies
  • Registries
  • Oncology & Carcinogenesis
  • Neuroblastoma
  • Minimally Invasive Surgical Procedures
  • Male
  • Kidney Neoplasms
  • Infant, Newborn
  • Infant