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Metastatic extrapulmonary small cell carcinoma to the cerebellopontine angle: a case report and review of the literature.

Publication ,  Journal Article
Theodros, D; Goodwin, CR; Crane, GM; Liauw, J; Kleinberg, L; Lim, M
Published in: Case Rep Oncol Med
2015

Extrapulmonary small cell carcinomas (EPSCC) are rare malignancies with poor patient prognoses. We present the case of a 63-year-old male who underwent surgical resection of a poorly differentiated small cell carcinoma, likely from a small intestinal primary tumor that metastasized to the cerebellopontine angle (CPA). A 63-year-old male presented with mild left facial paralysis, hearing loss, and balance instability. MRI revealed a 15 mm mass in the left CPA involving the internal auditory canal consistent with a vestibular schwannoma. Preoperative MRI eight weeks later demonstrated marked enlargement to 35 mm. The patient underwent a suboccipital craniectomy and the mass was grossly different visually and in consistency from a standard vestibular schwannoma. The final pathology revealed a poorly differentiated small cell carcinoma. Postoperative PET scan identified avid uptake in the small intestine suggestive of either a small intestinal primary tumor or additional metastatic disease. The patient underwent whole brain radiation therapy and chemotherapy and at last follow-up demonstrated improvement in his symptoms. Surgical resection and radiotherapy are potential treatment options to improve survival in patients diagnosed with NET brain metastases. We present the first documented case of skull base metastasis of a poorly differentiated small cell carcinoma involving the CPA.

Duke Scholars

Published In

Case Rep Oncol Med

DOI

ISSN

2090-6706

Publication Date

2015

Volume

2015

Start / End Page

847058

Location

United States
 

Citation

APA
Chicago
ICMJE
MLA
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Theodros, D., Goodwin, C. R., Crane, G. M., Liauw, J., Kleinberg, L., & Lim, M. (2015). Metastatic extrapulmonary small cell carcinoma to the cerebellopontine angle: a case report and review of the literature. Case Rep Oncol Med, 2015, 847058. https://doi.org/10.1155/2015/847058
Theodros, Debebe, C Rory Goodwin, Genevieve M. Crane, Jason Liauw, Lawrence Kleinberg, and Michael Lim. “Metastatic extrapulmonary small cell carcinoma to the cerebellopontine angle: a case report and review of the literature.Case Rep Oncol Med 2015 (2015): 847058. https://doi.org/10.1155/2015/847058.
Theodros D, Goodwin CR, Crane GM, Liauw J, Kleinberg L, Lim M. Metastatic extrapulmonary small cell carcinoma to the cerebellopontine angle: a case report and review of the literature. Case Rep Oncol Med. 2015;2015:847058.
Theodros, Debebe, et al. “Metastatic extrapulmonary small cell carcinoma to the cerebellopontine angle: a case report and review of the literature.Case Rep Oncol Med, vol. 2015, 2015, p. 847058. Pubmed, doi:10.1155/2015/847058.
Theodros D, Goodwin CR, Crane GM, Liauw J, Kleinberg L, Lim M. Metastatic extrapulmonary small cell carcinoma to the cerebellopontine angle: a case report and review of the literature. Case Rep Oncol Med. 2015;2015:847058.
Journal cover image

Published In

Case Rep Oncol Med

DOI

ISSN

2090-6706

Publication Date

2015

Volume

2015

Start / End Page

847058

Location

United States