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Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography.

Publication ,  Journal Article
Fenner, BJ; Tan, GSW; Tan, ACS; Yeo, IYS; Wong, TY; Cheung, GCM
Published in: Br J Ophthalmol
April 2018

PURPOSE: Optical coherence tomography angiography (OCT-A) potentially allows for rapid and non-invasive quantification of retinal capillary plexus density in various disease states. This study aims to identify the key features that influenced the repeatability of OCT-A measurements. METHODS: We obtained OCT-A images on two separate visits in 44 healthy eyes from 44 subjects, each imaged with using the Topcon DRI OCT Triton imaging system. The parafoveal vessel density within a 1.5 mm radius centred over the fovea was obtained with the built-in tool for the superficial and deep retinal plexuses. Repeatability of vessel density was determined by intraclass correlation (ICC) and mean variation. We evaluated several image parameters to determine their influence on the repeatability of vessel density measurement in each of the two capillary plexuses. RESULTS: The mean age of the subjects was 70.2±9.2 years, with 64% males. Mean parafoveal vessel density measurements for the first and second visits were 53.3±11.1 and 53.3±10.3 for the superficial plexus and 27.3±8.59 and 27.0±8.78 for the deep plexus. ICC analyses demonstrated that high fine vessel visibility, the absence of motion artefact and software-derived image quality score of 60 or above were necessary to obtain a good (ICC>0.6) or excellent (ICC>0.75) repeatability. CONCLUSIONS: Our study identified the imaging parameters that determined the repeatability of quantitative retinal vessel density measurements. These findings have implications in determining if OCT-A images can be used to accurately evaluate serial changes in retinal vessel density.

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Published In

Br J Ophthalmol

DOI

EISSN

1468-2079

Publication Date

April 2018

Volume

102

Issue

4

Start / End Page

509 / 514

Location

England

Related Subject Headings

  • Tomography, Optical Coherence
  • Retinal Vessels
  • Reproducibility of Results
  • Prospective Studies
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Humans
  • Fovea Centralis
  • Fluorescein Angiography
 

Citation

APA
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Fenner, B. J., Tan, G. S. W., Tan, A. C. S., Yeo, I. Y. S., Wong, T. Y., & Cheung, G. C. M. (2018). Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography. Br J Ophthalmol, 102(4), 509–514. https://doi.org/10.1136/bjophthalmol-2017-310700
Fenner, Beau J., Gavin S. W. Tan, Anna C. S. Tan, Ian Y. S. Yeo, Tien Yin Wong, and Gemmy C. M. Cheung. “Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography.Br J Ophthalmol 102, no. 4 (April 2018): 509–14. https://doi.org/10.1136/bjophthalmol-2017-310700.
Fenner BJ, Tan GSW, Tan ACS, Yeo IYS, Wong TY, Cheung GCM. Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography. Br J Ophthalmol. 2018 Apr;102(4):509–14.
Fenner, Beau J., et al. “Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography.Br J Ophthalmol, vol. 102, no. 4, Apr. 2018, pp. 509–14. Pubmed, doi:10.1136/bjophthalmol-2017-310700.
Fenner BJ, Tan GSW, Tan ACS, Yeo IYS, Wong TY, Cheung GCM. Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography. Br J Ophthalmol. 2018 Apr;102(4):509–514.

Published In

Br J Ophthalmol

DOI

EISSN

1468-2079

Publication Date

April 2018

Volume

102

Issue

4

Start / End Page

509 / 514

Location

England

Related Subject Headings

  • Tomography, Optical Coherence
  • Retinal Vessels
  • Reproducibility of Results
  • Prospective Studies
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Humans
  • Fovea Centralis
  • Fluorescein Angiography