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Retinal Vascular Imaging Markers and Incident Chronic Kidney Disease: A Prospective Cohort Study.

Publication ,  Journal Article
Yip, W; Ong, PG; Teo, BW; Cheung, CY-L; Tai, ES; Cheng, C-Y; Lamoureux, E; Wong, TY; Sabanayagam, C
Published in: Sci Rep
August 24, 2017

Retinal microvascular changes indicating microvascular dysfunction have been shown to be associated with chronic kidney disease (CKD) in cross-sectional studies, but findings were mixed in prospective studies. We aimed to evaluate the relationship between retinal microvascular parameters and incident CKD in an Asian population. We examined 1256 Malay adults aged 40-80 years from the Singapore Malay Eye Study, who attended both the baseline (2004-07) and the follow-up (2011-13) examinations and were free of prevalent CKD. We measured quantitative retinal vascular parameters (arteriolar and venular calibre, tortuosity, fractal dimension and branching angle) using a computer-assisted program (Singapore I Vessel Assessment, SIVA) and retinopathy (qualitative parameter) using the modified Airlie house classification system from baseline retinal photographs. Incident CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 + 25% decrease in eGFR during follow-up. Over a median follow-up period of 6 years, 78 (6.21%) developed CKD (70.5% had diabetes). In multivariable models, smaller retinal arterioles (hazards ratio [95% confidence interval] = 1.34 [1.00-1.78]), larger retinal venules (2.35 [1.12-5.94] and presence of retinopathy (2.54 [1.48-4.36]) were associated with incident CKD. Our findings suggest that retinal microvascular abnormalities may reflect subclinical renal microvascular abnormalities involved in the development of CKD.

Duke Scholars

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

August 24, 2017

Volume

7

Issue

1

Start / End Page

9374

Location

England

Related Subject Headings

  • Retinal Vessels
  • Retinal Diseases
  • Renal Insufficiency, Chronic
  • Prospective Studies
  • Population Surveillance
  • Middle Aged
  • Male
  • Kidney Function Tests
  • Incidental Findings
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yip, W., Ong, P. G., Teo, B. W., Cheung, C.-L., Tai, E. S., Cheng, C.-Y., … Sabanayagam, C. (2017). Retinal Vascular Imaging Markers and Incident Chronic Kidney Disease: A Prospective Cohort Study. Sci Rep, 7(1), 9374. https://doi.org/10.1038/s41598-017-09204-2
Yip, Wanfen, Peng Guan Ong, Boon Wee Teo, Carol Yim-Lui Cheung, E Shyong Tai, Ching-Yu Cheng, Ecosse Lamoureux, Tien Yin Wong, and Charumathi Sabanayagam. “Retinal Vascular Imaging Markers and Incident Chronic Kidney Disease: A Prospective Cohort Study.Sci Rep 7, no. 1 (August 24, 2017): 9374. https://doi.org/10.1038/s41598-017-09204-2.
Yip W, Ong PG, Teo BW, Cheung CY-L, Tai ES, Cheng C-Y, et al. Retinal Vascular Imaging Markers and Incident Chronic Kidney Disease: A Prospective Cohort Study. Sci Rep. 2017 Aug 24;7(1):9374.
Yip, Wanfen, et al. “Retinal Vascular Imaging Markers and Incident Chronic Kidney Disease: A Prospective Cohort Study.Sci Rep, vol. 7, no. 1, Aug. 2017, p. 9374. Pubmed, doi:10.1038/s41598-017-09204-2.
Yip W, Ong PG, Teo BW, Cheung CY-L, Tai ES, Cheng C-Y, Lamoureux E, Wong TY, Sabanayagam C. Retinal Vascular Imaging Markers and Incident Chronic Kidney Disease: A Prospective Cohort Study. Sci Rep. 2017 Aug 24;7(1):9374.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

August 24, 2017

Volume

7

Issue

1

Start / End Page

9374

Location

England

Related Subject Headings

  • Retinal Vessels
  • Retinal Diseases
  • Renal Insufficiency, Chronic
  • Prospective Studies
  • Population Surveillance
  • Middle Aged
  • Male
  • Kidney Function Tests
  • Incidental Findings
  • Humans