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Tubal ligation and ovarian cancer risk in African American women.

Publication ,  Journal Article
McNamara, C; Abbott, SE; Bandera, EV; Qin, B; Peres, LC; Camacho, F; Moorman, PG; Alberg, AJ; Barnholtz-Sloan, JS; Bondy, M; Cote, ML ...
Published in: Cancer Causes Control
October 2017

PURPOSE: Tubal ligation has been associated with reduced risk of epithelial ovarian cancer (EOC) in studies of primarily white women, but less is known about the association in African American (AA) women. We sought to evaluate the associations among 597 invasive ovarian cancer cases and 742 controls of AA descent recruited from the African American Cancer Epidemiology Study, a population-based case-control study in 11 geographical areas in the US. METHODS: Multivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) adjusted for potentially confounding factors. RESULTS: An inverse association between tubal ligation and EOC was observed that was not statistically significant (OR 0.88, 95% CI 0.68-1.14). However, an inverse association with EOC risk was observed among women who had a tubal ligation at age 35 years or older (OR 0.64; 95% CI 0.41-0.98), but not among those who had a tubal ligation before age 35 (OR 0.98; 95% CI 0.74-1.29) (p for interaction = 0.08). The association also varied considerably by tumor subtype. A strong inverse association was observed for endometrioid tumors (OR 0.31, 95% CI 0.14-0.70), whereas associations with mucinous (OR 0.87, 95% CI 0.36-2.12) and serous (OR 0.94, 95% CI 0.71-1.24) tumors were weaker and not statistically significant. A statistically non-significant positive association for clear cell tumors (OR 1.84, 95% CI 0.58-5.82) was based on a low number of cases. CONCLUSIONS: Our findings show that tubal ligation may confer a reduced risk for EOC among AA women that is comparable to the associations that have been previously observed in primarily white populations.

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Published In

Cancer Causes Control

DOI

EISSN

1573-7225

Publication Date

October 2017

Volume

28

Issue

10

Start / End Page

1033 / 1041

Location

Netherlands

Related Subject Headings

  • Young Adult
  • United States
  • Sterilization, Tubal
  • Risk Factors
  • Ovarian Neoplasms
  • Odds Ratio
  • Middle Aged
  • Logistic Models
  • Humans
  • Female
 

Citation

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McNamara, C., Abbott, S. E., Bandera, E. V., Qin, B., Peres, L. C., Camacho, F., … Terry, P. (2017). Tubal ligation and ovarian cancer risk in African American women. Cancer Causes Control, 28(10), 1033–1041. https://doi.org/10.1007/s10552-017-0943-6
McNamara, Chrissy, Sarah E. Abbott, Elisa V. Bandera, Bo Qin, Lauren C. Peres, Fabian Camacho, Patricia G. Moorman, et al. “Tubal ligation and ovarian cancer risk in African American women.Cancer Causes Control 28, no. 10 (October 2017): 1033–41. https://doi.org/10.1007/s10552-017-0943-6.
McNamara C, Abbott SE, Bandera EV, Qin B, Peres LC, Camacho F, et al. Tubal ligation and ovarian cancer risk in African American women. Cancer Causes Control. 2017 Oct;28(10):1033–41.
McNamara, Chrissy, et al. “Tubal ligation and ovarian cancer risk in African American women.Cancer Causes Control, vol. 28, no. 10, Oct. 2017, pp. 1033–41. Pubmed, doi:10.1007/s10552-017-0943-6.
McNamara C, Abbott SE, Bandera EV, Qin B, Peres LC, Camacho F, Moorman PG, Alberg AJ, Barnholtz-Sloan JS, Bondy M, Cote ML, Funkhouser E, Peters ES, Schwartz AG, Schildkraut JM, Terry P. Tubal ligation and ovarian cancer risk in African American women. Cancer Causes Control. 2017 Oct;28(10):1033–1041.
Journal cover image

Published In

Cancer Causes Control

DOI

EISSN

1573-7225

Publication Date

October 2017

Volume

28

Issue

10

Start / End Page

1033 / 1041

Location

Netherlands

Related Subject Headings

  • Young Adult
  • United States
  • Sterilization, Tubal
  • Risk Factors
  • Ovarian Neoplasms
  • Odds Ratio
  • Middle Aged
  • Logistic Models
  • Humans
  • Female