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History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium.

Publication ,  Journal Article
Minlikeeva, AN; Freudenheim, JL; Eng, KH; Cannioto, RA; Friel, G; Szender, JB; Segal, B; Odunsi, K; Mayor, P; Diergaarde, B; Zsiros, E; Wu, AH ...
Published in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
September 2017

Background: Comorbidities can affect survival of ovarian cancer patients by influencing treatment efficacy. However, little evidence exists on the association between individual concurrent comorbidities and prognosis in ovarian cancer patients.Methods: Among patients diagnosed with invasive ovarian carcinoma who participated in 23 studies included in the Ovarian Cancer Association Consortium, we explored associations between histories of endometriosis; asthma; depression; osteoporosis; and autoimmune, gallbladder, kidney, liver, and neurological diseases and overall and progression-free survival. Using Cox proportional hazards regression models adjusted for age at diagnosis, stage of disease, histology, and study site, we estimated pooled HRs and 95% confidence intervals to assess associations between each comorbidity and ovarian cancer outcomes.Results: None of the comorbidities were associated with ovarian cancer outcome in the overall sample nor in strata defined by histologic subtype, weight status, age at diagnosis, or stage of disease (local/regional vs. advanced).Conclusions: Histories of endometriosis; asthma; depression; osteoporosis; and autoimmune, gallbladder, kidney, liver, or neurologic diseases were not associated with ovarian cancer overall or progression-free survival.Impact: These previously diagnosed chronic diseases do not appear to affect ovarian cancer prognosis. Cancer Epidemiol Biomarkers Prev; 26(9); 1470-3. ©2017 AACR.

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Published In

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

DOI

EISSN

1538-7755

ISSN

1055-9965

Publication Date

September 2017

Volume

26

Issue

9

Start / End Page

1470 / 1473

Related Subject Headings

  • Survival Analysis
  • Ovarian Neoplasms
  • Humans
  • Female
  • Epidemiology
  • Disease-Free Survival
  • Comorbidity
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences
 

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Minlikeeva, A. N., Freudenheim, J. L., Eng, K. H., Cannioto, R. A., Friel, G., Szender, J. B., … Australian Ovarian Cancer Study Group, . (2017). History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium. Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 26(9), 1470–1473. https://doi.org/10.1158/1055-9965.epi-17-0367
Minlikeeva, Albina N., Jo L. Freudenheim, Kevin H. Eng, Rikki A. Cannioto, Grace Friel, J Brian Szender, Brahm Segal, et al. “History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium.Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 26, no. 9 (September 2017): 1470–73. https://doi.org/10.1158/1055-9965.epi-17-0367.
Minlikeeva AN, Freudenheim JL, Eng KH, Cannioto RA, Friel G, Szender JB, et al. History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2017 Sep;26(9):1470–3.
Minlikeeva, Albina N., et al. “History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium.Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, vol. 26, no. 9, Sept. 2017, pp. 1470–73. Epmc, doi:10.1158/1055-9965.epi-17-0367.
Minlikeeva AN, Freudenheim JL, Eng KH, Cannioto RA, Friel G, Szender JB, Segal B, Odunsi K, Mayor P, Diergaarde B, Zsiros E, Kelemen LE, Köbel M, Steed H, deFazio A, Jordan SJ, Fasching PA, Beckmann MW, Risch HA, Rossing MA, Doherty JA, Chang-Claude J, Goodman MT, Dörk T, Edwards R, Modugno F, Ness RB, Matsuo K, Mizuno M, Karlan BY, Goode EL, Kjær SK, Høgdall E, Schildkraut JM, Terry KL, Cramer DW, Bandera EV, Paddock LE, Kiemeney LA, Massuger LFAG, Sutphen R, Anton-Culver H, Ziogas A, Menon U, Gayther SA, Ramus SJ, Gentry-Maharaj A, Pearce CL, Wu AH, Kupryjanczyk J, Jensen A, Webb PM, Moysich KB, Ovarian Cancer Association Consortium, Australian Ovarian Cancer Study Group. History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2017 Sep;26(9):1470–1473.

Published In

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

DOI

EISSN

1538-7755

ISSN

1055-9965

Publication Date

September 2017

Volume

26

Issue

9

Start / End Page

1470 / 1473

Related Subject Headings

  • Survival Analysis
  • Ovarian Neoplasms
  • Humans
  • Female
  • Epidemiology
  • Disease-Free Survival
  • Comorbidity
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences