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A Systematic Review of Clinical Outcomes and Prognostic Factors for Patients Undergoing Surgery for Spinal Metastases Secondary to Breast Cancer

Publication ,  Journal Article
Sciubba, DM; Goodwin, CR; Yurter, A; Ju, D; Gokaslan, ZL; Fisher, C; Rhines, LD; Fehlings, MG; Fourney, DR; Mendel, E; Laufer, I; Patel, SR ...
Published in: Global Spine Journal
August 1, 2016

Study Design Review of the literature. Objective Surgery and cement augmentation procedures are effective palliative treatment of symptomatic spinal metastases. Our objective is to systematically review the literature to describe the survival, prognostic factors, and clinical outcomes of surgery and cement augmentation procedures for breast cancer metastases to the spine. Methods We performed a literature review using PubMed to identify articles that reported outcomes and/or prognostic factors of the breast cancer patient population with spinal metastases treated with any surgical technique since 1990. Results The median postoperative survival for metastatic breast cancer was 21.7 months (8.2 to 36 months), the mean rate of any pain improvement was 92.9% (76 to 100%), the mean rate of neurologic improvement was 63.8% (53 to 100%), the mean rate of neurologic decline was 4.1% (0 to 8%), and the local tumor control rate was 92.6% (89 to 100%). Kyphoplasty studies reported a high rate of pain control in selected patients. Negative prognostic variables included hormonal (estrogen and progesterone) and human epidermal growth factor receptor 2 (HER2) receptor refractory tumor status, high degree of axillary lymph node involvement, and short disease-free interval (DFI). All other clinical or prognostic parameters were of low or insufficient strength. Conclusion With respect to clinical outcomes, surgery consistently yielded neurologic improvements in patients presenting with a deficit with a minimal risk of worsening; however, negative prognostic factors associated with shorter survival following surgery include estrogen receptor/progesterone receptor negativity, HER2 negativity, and a short DFI.

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Published In

Global Spine Journal

DOI

EISSN

2192-5690

ISSN

2192-5682

Publication Date

August 1, 2016

Volume

6

Issue

5

Start / End Page

482 / 496

Related Subject Headings

  • 3202 Clinical sciences
 

Citation

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Chicago
ICMJE
MLA
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Sciubba, D. M., Goodwin, C. R., Yurter, A., Ju, D., Gokaslan, Z. L., Fisher, C., … Clarke, M. J. (2016). A Systematic Review of Clinical Outcomes and Prognostic Factors for Patients Undergoing Surgery for Spinal Metastases Secondary to Breast Cancer. Global Spine Journal, 6(5), 482–496. https://doi.org/10.1055/s-0035-1564807
Sciubba, D. M., C. R. Goodwin, A. Yurter, D. Ju, Z. L. Gokaslan, C. Fisher, L. D. Rhines, et al. “A Systematic Review of Clinical Outcomes and Prognostic Factors for Patients Undergoing Surgery for Spinal Metastases Secondary to Breast Cancer.” Global Spine Journal 6, no. 5 (August 1, 2016): 482–96. https://doi.org/10.1055/s-0035-1564807.
Sciubba DM, Goodwin CR, Yurter A, Ju D, Gokaslan ZL, Fisher C, et al. A Systematic Review of Clinical Outcomes and Prognostic Factors for Patients Undergoing Surgery for Spinal Metastases Secondary to Breast Cancer. Global Spine Journal. 2016 Aug 1;6(5):482–96.
Sciubba, D. M., et al. “A Systematic Review of Clinical Outcomes and Prognostic Factors for Patients Undergoing Surgery for Spinal Metastases Secondary to Breast Cancer.” Global Spine Journal, vol. 6, no. 5, Aug. 2016, pp. 482–96. Scopus, doi:10.1055/s-0035-1564807.
Sciubba DM, Goodwin CR, Yurter A, Ju D, Gokaslan ZL, Fisher C, Rhines LD, Fehlings MG, Fourney DR, Mendel E, Laufer I, Bettegowda C, Patel SR, Rampersaud YR, Sahgal A, Reynolds J, Chou D, Weber MH, Clarke MJ. A Systematic Review of Clinical Outcomes and Prognostic Factors for Patients Undergoing Surgery for Spinal Metastases Secondary to Breast Cancer. Global Spine Journal. 2016 Aug 1;6(5):482–496.
Journal cover image

Published In

Global Spine Journal

DOI

EISSN

2192-5690

ISSN

2192-5682

Publication Date

August 1, 2016

Volume

6

Issue

5

Start / End Page

482 / 496

Related Subject Headings

  • 3202 Clinical sciences