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Clinical Decision Making: Integrating Advances in the Molecular Understanding of Spine Tumors.

Publication ,  Journal Article
Goodwin, CR; Abu-Bonsrah, N; Bilsky, MH; Reynolds, JJ; Rhines, LD; Laufer, I; Disch, AC; Bozsodi, A; Patel, SR; Gokaslan, ZL; Sciubba, DM ...
Published in: Spine (Phila Pa 1976)
October 15, 2016

STUDY DESIGN: Literature review. OBJECTIVE: To describe advancements in molecular techniques, biomarkers, technology, and targeted therapeutics and the potential these modalities hold to predict treatment paradigms, clinical outcomes, and/or survival in patients diagnosed with primary spinal column tumors. SUMMARY OF BACKGROUND DATA: Advances in molecular technologies and techniques have influenced the prevention, diagnosis, and overall management of patients diagnosed with cancer. Assessment of genomic, proteomic alterations, epigenetic, and posttranslational modifications as well as developments in diagnostic modalities and targeted therapeutics, although the best studied in nonspinal metastatic disease, have led to increased understanding of spine oncology that is expected to improve patient outcomes. In this manuscript, the technological advancements that are expected to change the landscape of spinal oncology are discussed with a focus on how these technologies will aid in clinical decision-making for patients diagnosed with primary spinal tumors. METHODS: A review of the literature was performed focusing on studies that integrated next-generation sequencing, circulating tumor cells/circulating tumor DNA, advances in imaging modalities and/or radiotherapy in the diagnosis and treatment of cancer. RESULTS: We discuss genetic and epigenetic drivers, aberrations in receptor tyrosine kinase signaling, and emerging therapeutic strategies that include receptor tyrosine kinase inhibitors, immunotherapy strategies, and vaccine-based cancer prevention strategies. CONCLUSION: The wide range of approaches currently in use and the emerging technologies yet to be fully realized will allow for better development of rationale therapeutics to improve patient outcomes. LEVEL OF EVIDENCE: N/A.

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Published In

Spine (Phila Pa 1976)

DOI

EISSN

1528-1159

Publication Date

October 15, 2016

Volume

41 Suppl 20

Start / End Page

S171 / S177

Location

United States

Related Subject Headings

  • Spinal Neoplasms
  • Proteomics
  • Orthopedics
  • Humans
  • High-Throughput Nucleotide Sequencing
  • Clinical Decision-Making
  • Biomarkers, Tumor
  • 4201 Allied health and rehabilitation science
  • 3209 Neurosciences
  • 3202 Clinical sciences
 

Citation

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Goodwin, C. R., Abu-Bonsrah, N., Bilsky, M. H., Reynolds, J. J., Rhines, L. D., Laufer, I., … Bettegowda, C. (2016). Clinical Decision Making: Integrating Advances in the Molecular Understanding of Spine Tumors. Spine (Phila Pa 1976), 41 Suppl 20, S171–S177. https://doi.org/10.1097/BRS.0000000000001836
Goodwin, C Rory, Nancy Abu-Bonsrah, Mark H. Bilsky, Jeremy J. Reynolds, Laurence D. Rhines, Ilya Laufer, Alexander C. Disch, et al. “Clinical Decision Making: Integrating Advances in the Molecular Understanding of Spine Tumors.Spine (Phila Pa 1976) 41 Suppl 20 (October 15, 2016): S171–77. https://doi.org/10.1097/BRS.0000000000001836.
Goodwin CR, Abu-Bonsrah N, Bilsky MH, Reynolds JJ, Rhines LD, Laufer I, et al. Clinical Decision Making: Integrating Advances in the Molecular Understanding of Spine Tumors. Spine (Phila Pa 1976). 2016 Oct 15;41 Suppl 20:S171–7.
Goodwin, C. Rory, et al. “Clinical Decision Making: Integrating Advances in the Molecular Understanding of Spine Tumors.Spine (Phila Pa 1976), vol. 41 Suppl 20, Oct. 2016, pp. S171–77. Pubmed, doi:10.1097/BRS.0000000000001836.
Goodwin CR, Abu-Bonsrah N, Bilsky MH, Reynolds JJ, Rhines LD, Laufer I, Disch AC, Bozsodi A, Patel SR, Gokaslan ZL, Sciubba DM, Bettegowda C. Clinical Decision Making: Integrating Advances in the Molecular Understanding of Spine Tumors. Spine (Phila Pa 1976). 2016 Oct 15;41 Suppl 20:S171–S177.

Published In

Spine (Phila Pa 1976)

DOI

EISSN

1528-1159

Publication Date

October 15, 2016

Volume

41 Suppl 20

Start / End Page

S171 / S177

Location

United States

Related Subject Headings

  • Spinal Neoplasms
  • Proteomics
  • Orthopedics
  • Humans
  • High-Throughput Nucleotide Sequencing
  • Clinical Decision-Making
  • Biomarkers, Tumor
  • 4201 Allied health and rehabilitation science
  • 3209 Neurosciences
  • 3202 Clinical sciences