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Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function.

Publication ,  Journal Article
Huang, YZ; Wang, Q; Won, S; Luo, ZG; Xiong, WC; Mei, L
Published in: Int J Dev Neurosci
2002

The synapse-specific synthesis of the acetylcholine receptor (AChR) is mediated by multiple mechanisms including compartmentalized signaling induced by neuregulin (NRG). This paper presents evidence that NRG receptors--ErbB receptor tyrosine kinases interact with distinct PDZ domain-containing proteins that are localized at the neuromuscular junction (NMJ). ErbB4 associates with the PSD-95 (also known as SAP90)-family members including PSD-95, SAP97, and SAP102 whereas ErbB2 interacts with Erbin and PICK1. Although, ErbB kinases are concentrated at the NMJ, they are not colocalized with the AChR in cultured muscle cells even in the presence of agrin. Co-expression of PSD-95 causes ErbB4 to form clusters in COS cells. We propose that PDZ domain-containing proteins play a role in anchoring ErbB proteins at the neuromuscular junction, and/or mediating downstream signaling pathways. Such mechanisms could be important for the maintenance and function of the synapse.

Duke Scholars

Published In

Int J Dev Neurosci

DOI

ISSN

0736-5748

Publication Date

2002

Volume

20

Issue

3-5

Start / End Page

173 / 185

Location

United States

Related Subject Headings

  • Tyrosine
  • Transcription Factors
  • Synaptic Transmission
  • Signal Transduction
  • Receptors, Cholinergic
  • Receptor, ErbB-4
  • RNA, Messenger
  • Protein Structure, Tertiary
  • Phosphorylation
  • Nuclear Proteins
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Huang, Y. Z., Wang, Q., Won, S., Luo, Z. G., Xiong, W. C., & Mei, L. (2002). Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function. Int J Dev Neurosci, 20(3–5), 173–185. https://doi.org/10.1016/s0736-5748(02)00011-4
Huang, Yang Z., Qiang Wang, Sandra Won, Zhen G. Luo, Wen C. Xiong, and Lin Mei. “Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function.Int J Dev Neurosci 20, no. 3–5 (2002): 173–85. https://doi.org/10.1016/s0736-5748(02)00011-4.
Huang YZ, Wang Q, Won S, Luo ZG, Xiong WC, Mei L. Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function. Int J Dev Neurosci. 2002;20(3–5):173–85.
Huang, Yang Z., et al. “Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function.Int J Dev Neurosci, vol. 20, no. 3–5, 2002, pp. 173–85. Pubmed, doi:10.1016/s0736-5748(02)00011-4.
Huang YZ, Wang Q, Won S, Luo ZG, Xiong WC, Mei L. Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function. Int J Dev Neurosci. 2002;20(3–5):173–185.
Journal cover image

Published In

Int J Dev Neurosci

DOI

ISSN

0736-5748

Publication Date

2002

Volume

20

Issue

3-5

Start / End Page

173 / 185

Location

United States

Related Subject Headings

  • Tyrosine
  • Transcription Factors
  • Synaptic Transmission
  • Signal Transduction
  • Receptors, Cholinergic
  • Receptor, ErbB-4
  • RNA, Messenger
  • Protein Structure, Tertiary
  • Phosphorylation
  • Nuclear Proteins