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Is Corneal Arcus Independently Associated With Incident Cardiovascular Disease in Asians?

Publication ,  Journal Article
Wong, MYZ; Man, REK; Gupta, P; Lim, SH; Lim, B; Tham, Y-C; Sabanayagam, C; Wong, TY; Cheng, C-Y; Lamoureux, EL
Published in: Am J Ophthalmol
November 2017

PURPOSE: To examine the longitudinal relationship between baseline corneal arcus (CA) and incident cardiovascular disease (CVD) in ethnic Indian and Malay adults in Singapore. DESIGN: Population-based cohort study. METHODS: Indian and Malay adults aged 40-80 years were recruited for baseline and 6-year follow-up visits between 2004-2009 and 2010-2015, respectively (follow-up response rate 73.9%). CA was assessed by ophthalmologists using slit-lamp biomicroscopy. The main outcome was self-reported incident CVD, defined as new myocardial infarction, angina pectoris, or stroke, which developed between baseline and follow-up. Multivariable logistic regression models assessed independent associations between baseline CA and incident CVD, adjusting for traditional CVD risk factors including age, sex, serum cholesterol, hypertension, diabetes, and smoking. We further conducted sex-stratified analyses to identify possible effect modifications. RESULTS: Of the total 3637 participants (overall mean [SD] age: 56 [9] years, 46% male) with available follow-up data, without history of CVD at baseline, 208 (5.7%) incident CVD cases were reported. Participants with CA were more likely to have incident CVD (7.5%) than those without (4.9%). After controlling for traditional CVD risk factors, CA was independently associated with incident CVD (odds ratio [95% confidence interval]: 1.52 [1.07-2.16]) in adjusted models. In sex-stratified models, associations between CA and incident CVD were seen in men (1.73 [1.12-2.67]) and not in women (1.05 [0.56-1.97]). CONCLUSIONS: CA is associated with incident CVD, independent of serum lipids and traditional CVD risk factors, in ethnic Malay and Indian men. Our finding suggests that CA is an additional observable indicator of CVD in men.

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Published In

Am J Ophthalmol

DOI

EISSN

1879-1891

Publication Date

November 2017

Volume

183

Start / End Page

99 / 106

Location

United States

Related Subject Headings

  • Time Factors
  • Singapore
  • Sex Distribution
  • Risk Factors
  • Risk Assessment
  • Prospective Studies
  • Population Surveillance
  • Ophthalmology & Optometry
  • Middle Aged
  • Microscopy, Acoustic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wong, M. Y. Z., Man, R. E. K., Gupta, P., Lim, S. H., Lim, B., Tham, Y.-C., … Lamoureux, E. L. (2017). Is Corneal Arcus Independently Associated With Incident Cardiovascular Disease in Asians? Am J Ophthalmol, 183, 99–106. https://doi.org/10.1016/j.ajo.2017.09.002
Wong, Mark Yu Zheng, Ryan Eyn Kidd Man, Preeti Gupta, Sing Hui Lim, Blanche Lim, Yih-Chung Tham, Charumathi Sabanayagam, Tien Yin Wong, Ching-Yu Cheng, and Ecosse Luc Lamoureux. “Is Corneal Arcus Independently Associated With Incident Cardiovascular Disease in Asians?Am J Ophthalmol 183 (November 2017): 99–106. https://doi.org/10.1016/j.ajo.2017.09.002.
Wong MYZ, Man REK, Gupta P, Lim SH, Lim B, Tham Y-C, et al. Is Corneal Arcus Independently Associated With Incident Cardiovascular Disease in Asians? Am J Ophthalmol. 2017 Nov;183:99–106.
Wong, Mark Yu Zheng, et al. “Is Corneal Arcus Independently Associated With Incident Cardiovascular Disease in Asians?Am J Ophthalmol, vol. 183, Nov. 2017, pp. 99–106. Pubmed, doi:10.1016/j.ajo.2017.09.002.
Wong MYZ, Man REK, Gupta P, Lim SH, Lim B, Tham Y-C, Sabanayagam C, Wong TY, Cheng C-Y, Lamoureux EL. Is Corneal Arcus Independently Associated With Incident Cardiovascular Disease in Asians? Am J Ophthalmol. 2017 Nov;183:99–106.
Journal cover image

Published In

Am J Ophthalmol

DOI

EISSN

1879-1891

Publication Date

November 2017

Volume

183

Start / End Page

99 / 106

Location

United States

Related Subject Headings

  • Time Factors
  • Singapore
  • Sex Distribution
  • Risk Factors
  • Risk Assessment
  • Prospective Studies
  • Population Surveillance
  • Ophthalmology & Optometry
  • Middle Aged
  • Microscopy, Acoustic