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The impact of retardance pattern variability on nerve fiber layer measurements over time using GDx with variable and enhanced corneal compensation.

Publication ,  Journal Article
Grewal, DS; Sehi, M; Cook, RJ; Greenfield, DS; Advanced Imaging in Glaucoma Study Group,
Published in: Invest Ophthalmol Vis Sci
June 23, 2011

PURPOSE: To examine the impact of retardance pattern variability on retinal nerve fiber layer (RNFL) measurements over time using scanning laser polarimetry with variable (GDxVCC) and enhanced corneal compensation (GDxECC; both by Carl Zeiss Meditec, Inc., Dublin, CA). METHODS: Glaucoma suspect and glaucomatous eyes with 4 years of follow-up participating in the Advanced Imaging in Glaucoma Study were prospectively enrolled. All eyes underwent standard automated perimetry (SAP), GDxVCC, and GDxECC imaging every 6 months. SAP progression was determined with point-wise linear regression analysis of SAP sensitivity values. Typical scan score (TSS) values were extracted as a measure of retardance image quality; an atypical retardation pattern (ARP) was defined as TSS < 80. TSS fluctuation over time was measured using three parameters: change in TSS from baseline, absolute difference (maximum minus minimum TSS value), and TSS variance. Linear mixed-effects models that accommodated the association between the two eyes were constructed to evaluate the relationship between change in TSS and RNFL thickness over time. RESULTS: Eighty-six eyes (51 suspected glaucoma, 35 glaucomatous) of 45 patients were enrolled. Twenty (23.3%) eyes demonstrated SAP progression. There was significantly greater fluctuation in TSS over time with GDxVCC compared with GDxECC as measured by absolute difference (18.40 ± 15.35 units vs. 2.50 ± 4.69 units; P < 0.001), TSS variance (59.63 ± 87.27 units vs. 3.82 ± 9.63 units, P < 0.001), and change in TSS from baseline (-0.83 ± 11.2 vs. 0.25 ± 2.9, P = 0.01). The change in TSS over time significantly (P = 0.006) influenced the TSNIT average RNFL thickness when measured by GDxVCC but not by GDxECC. CONCLUSIONS: Longitudinal images obtained with GDxECC have significantly less variability in TSS and retardance patterns and have reduced bias produced by ARP on RNFL progression assessment.

Duke Scholars

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

June 23, 2011

Volume

52

Issue

7

Start / End Page

4516 / 4524

Location

United States

Related Subject Headings

  • Visual Fields
  • Time Factors
  • Retinal Ganglion Cells
  • Prospective Studies
  • Optic Nerve Diseases
  • Optic Disk
  • Ophthalmoscopy
  • Ophthalmology & Optometry
  • Ocular Hypertension
  • Nerve Fibers
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Grewal, D. S., Sehi, M., Cook, R. J., Greenfield, D. S., & Advanced Imaging in Glaucoma Study Group, . (2011). The impact of retardance pattern variability on nerve fiber layer measurements over time using GDx with variable and enhanced corneal compensation. Invest Ophthalmol Vis Sci, 52(7), 4516–4524. https://doi.org/10.1167/iovs.10-5969
Grewal, Dilraj S., Mitra Sehi, Richard J. Cook, David S. Greenfield, and David S. Advanced Imaging in Glaucoma Study Group. “The impact of retardance pattern variability on nerve fiber layer measurements over time using GDx with variable and enhanced corneal compensation.Invest Ophthalmol Vis Sci 52, no. 7 (June 23, 2011): 4516–24. https://doi.org/10.1167/iovs.10-5969.
Grewal DS, Sehi M, Cook RJ, Greenfield DS, Advanced Imaging in Glaucoma Study Group. The impact of retardance pattern variability on nerve fiber layer measurements over time using GDx with variable and enhanced corneal compensation. Invest Ophthalmol Vis Sci. 2011 Jun 23;52(7):4516–24.
Grewal, Dilraj S., et al. “The impact of retardance pattern variability on nerve fiber layer measurements over time using GDx with variable and enhanced corneal compensation.Invest Ophthalmol Vis Sci, vol. 52, no. 7, June 2011, pp. 4516–24. Pubmed, doi:10.1167/iovs.10-5969.
Grewal DS, Sehi M, Cook RJ, Greenfield DS, Advanced Imaging in Glaucoma Study Group. The impact of retardance pattern variability on nerve fiber layer measurements over time using GDx with variable and enhanced corneal compensation. Invest Ophthalmol Vis Sci. 2011 Jun 23;52(7):4516–4524.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

June 23, 2011

Volume

52

Issue

7

Start / End Page

4516 / 4524

Location

United States

Related Subject Headings

  • Visual Fields
  • Time Factors
  • Retinal Ganglion Cells
  • Prospective Studies
  • Optic Nerve Diseases
  • Optic Disk
  • Ophthalmoscopy
  • Ophthalmology & Optometry
  • Ocular Hypertension
  • Nerve Fibers