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Blood Epigenetic Age may Predict Cancer Incidence and Mortality.

Publication ,  Journal Article
Zheng, Y; Joyce, BT; Colicino, E; Liu, L; Zhang, W; Dai, Q; Shrubsole, MJ; Kibbe, WA; Gao, T; Zhang, Z; Jafari, N; Vokonas, P; Schwartz, J ...
Published in: EBioMedicine
March 2016

Biological measures of aging are important for understanding the health of an aging population, with epigenetics particularly promising. Previous studies found that tumor tissue is epigenetically older than its donors are chronologically. We examined whether blood Δage (the discrepancy between epigenetic and chronological ages) can predict cancer incidence or mortality, thus assessing its potential as a cancer biomarker. In a prospective cohort, Δage and its rate of change over time were calculated in 834 blood leukocyte samples collected from 442 participants free of cancer at blood draw. About 3-5 years before cancer onset or death, Δage was associated with cancer risks in a dose-responsive manner (P = 0.02) and a one-year increase in Δage was associated with cancer incidence (HR: 1.06, 95% CI: 1.02-1.10) and mortality (HR: 1.17, 95% CI: 1.07-1.28). Participants with smaller Δage and decelerated epigenetic aging over time had the lowest risks of cancer incidence (P = 0.003) and mortality (P = 0.02). Δage was associated with cancer incidence in a 'J-shaped' manner for subjects examined pre-2003, and with cancer mortality in a time-varying manner. We conclude that blood epigenetic age may mirror epigenetic abnormalities related to cancer development, potentially serving as a minimally invasive biomarker for cancer early detection.

Duke Scholars

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Published In

EBioMedicine

DOI

EISSN

2352-3964

Publication Date

March 2016

Volume

5

Start / End Page

68 / 73

Location

Netherlands

Related Subject Headings

  • Neoplasms
  • Middle Aged
  • Male
  • Humans
  • Female
  • Epigenomics
  • DNA Methylation
  • Aging
  • Aged
  • 4202 Epidemiology
 

Citation

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Zheng, Y., Joyce, B. T., Colicino, E., Liu, L., Zhang, W., Dai, Q., … Hou, L. (2016). Blood Epigenetic Age may Predict Cancer Incidence and Mortality. EBioMedicine, 5, 68–73. https://doi.org/10.1016/j.ebiom.2016.02.008
Zheng, Yinan, Brian T. Joyce, Elena Colicino, Lei Liu, Wei Zhang, Qi Dai, Martha J. Shrubsole, et al. “Blood Epigenetic Age may Predict Cancer Incidence and Mortality.EBioMedicine 5 (March 2016): 68–73. https://doi.org/10.1016/j.ebiom.2016.02.008.
Zheng Y, Joyce BT, Colicino E, Liu L, Zhang W, Dai Q, et al. Blood Epigenetic Age may Predict Cancer Incidence and Mortality. EBioMedicine. 2016 Mar;5:68–73.
Zheng, Yinan, et al. “Blood Epigenetic Age may Predict Cancer Incidence and Mortality.EBioMedicine, vol. 5, Mar. 2016, pp. 68–73. Pubmed, doi:10.1016/j.ebiom.2016.02.008.
Zheng Y, Joyce BT, Colicino E, Liu L, Zhang W, Dai Q, Shrubsole MJ, Kibbe WA, Gao T, Zhang Z, Jafari N, Vokonas P, Schwartz J, Baccarelli AA, Hou L. Blood Epigenetic Age may Predict Cancer Incidence and Mortality. EBioMedicine. 2016 Mar;5:68–73.
Journal cover image

Published In

EBioMedicine

DOI

EISSN

2352-3964

Publication Date

March 2016

Volume

5

Start / End Page

68 / 73

Location

Netherlands

Related Subject Headings

  • Neoplasms
  • Middle Aged
  • Male
  • Humans
  • Female
  • Epigenomics
  • DNA Methylation
  • Aging
  • Aged
  • 4202 Epidemiology