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Plasmodium falciparum parasitaemia in the first half of pregnancy, uterine and umbilical artery blood flow, and foetal growth: a longitudinal Doppler ultrasound study.

Publication ,  Journal Article
Griffin, JB; Lokomba, V; Landis, SH; Thorp, JM; Herring, AH; Tshefu, AK; Rogerson, SJ; Meshnick, SR
Published in: Malaria journal
September 2012

During early pregnancy, the placenta develops to meet the metabolic demands of the foetus. The objective of this analysis was to examine the effect of malaria parasitaemia prior to 20 weeks' gestation on subsequent changes in uterine and umbilical artery blood flow and intrauterine growth restriction.Data were analysed from 548 antenatal visits after 20 weeks' gestation of 128 women, which included foetal biometric measures and interrogation of uterine and umbilical artery blood flow. Linear mixed effect models estimated the effect of early pregnancy malaria parasitaemia on uterine and umbilical artery resistance indices. Log-binomial models with generalized estimating equations estimated the effect of early pregnancy malaria parasitaemia on the risk of intrauterine growth restriction.There were differential effects of early pregnancy malaria parasitaemia on uterine artery resistance by nutritional status, with decreased uterine artery resistance among nourished women with early pregnancy malaria and increased uterine artery resistance among undernourished women with early pregnancy malaria. Among primigravidae, early pregnancy malaria parasitaemia decreased umbilical artery resistance in the late third trimester, likely reflecting adaptive villous angiogenesis. In fully adjusted models, primigravidae with early pregnancy malaria parasitaemia had 3.6 times the risk of subsequent intrauterine growth restriction (95% CI: 2.1, 6.2) compared to the referent group of multigravidae with no early pregnancy malaria parasitaemia.Early pregnancy malaria parasitaemia affects uterine and umbilical artery blood flow, possibly due to alterations in placentation and angiogenesis, respectively. Among primigravidae, early pregnancy malaria parasitaemia increases the risk of intrauterine growth restriction. The findings support the initiation of malaria parasitaemia prevention and control efforts earlier in pregnancy.

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Published In

Malaria journal

DOI

EISSN

1475-2875

ISSN

1475-2875

Publication Date

September 2012

Volume

11

Start / End Page

319

Related Subject Headings

  • Young Adult
  • Uterus
  • Umbilical Arteries
  • Ultrasonography
  • Tropical Medicine
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Parasitemia
  • Male
  • Malaria, Falciparum
 

Citation

APA
Chicago
ICMJE
MLA
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Griffin, J. B., Lokomba, V., Landis, S. H., Thorp, J. M., Herring, A. H., Tshefu, A. K., … Meshnick, S. R. (2012). Plasmodium falciparum parasitaemia in the first half of pregnancy, uterine and umbilical artery blood flow, and foetal growth: a longitudinal Doppler ultrasound study. Malaria Journal, 11, 319. https://doi.org/10.1186/1475-2875-11-319
Griffin, Jennifer B., Victor Lokomba, Sarah H. Landis, John M. Thorp, Amy H. Herring, Antoinette K. Tshefu, Stephen J. Rogerson, and Steven R. Meshnick. “Plasmodium falciparum parasitaemia in the first half of pregnancy, uterine and umbilical artery blood flow, and foetal growth: a longitudinal Doppler ultrasound study.Malaria Journal 11 (September 2012): 319. https://doi.org/10.1186/1475-2875-11-319.
Griffin, Jennifer B., et al. “Plasmodium falciparum parasitaemia in the first half of pregnancy, uterine and umbilical artery blood flow, and foetal growth: a longitudinal Doppler ultrasound study.Malaria Journal, vol. 11, Sept. 2012, p. 319. Epmc, doi:10.1186/1475-2875-11-319.
Griffin JB, Lokomba V, Landis SH, Thorp JM, Herring AH, Tshefu AK, Rogerson SJ, Meshnick SR. Plasmodium falciparum parasitaemia in the first half of pregnancy, uterine and umbilical artery blood flow, and foetal growth: a longitudinal Doppler ultrasound study. Malaria journal. 2012 Sep;11:319.
Journal cover image

Published In

Malaria journal

DOI

EISSN

1475-2875

ISSN

1475-2875

Publication Date

September 2012

Volume

11

Start / End Page

319

Related Subject Headings

  • Young Adult
  • Uterus
  • Umbilical Arteries
  • Ultrasonography
  • Tropical Medicine
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Parasitemia
  • Male
  • Malaria, Falciparum