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Bimodal decompression sickness onset times are not related to dive type or event severity.

Publication ,  Journal Article
King, AE; Murphy, FG; Howle, LE
Published in: Computers in biology and medicine
December 2017

Human decompression sickness (DCS) is a condition associated with depressurization during underwater diving. Human research dive trial data containing dive outcome (DCS, no-DCS) and symptom information are used to calibrate probabilistic DCS models. DCS symptom onset time information is visualized using occurrence density functions (ODF) which plot the DCS onset rate per unit time. For the BIG292 human dive trial data set, a primary U.S. Navy model calibration set, the ODFs are bimodal, however probabilistic models do not produce bimodal ODFs. We investigate the source of bimodality by partitioning the BIG292 data based on dive type, DCS event severity, DCS symptom type, institution, and chronology of dive trial. All but one variant of data partitioning resulted in a bimodal or ambiguously shaped ODF, indicating that ODF bimodality is not related to the dive type or the DCS event severity. Rather, we find that the dive trial medical surveillance protocol used to determine DCS symptom onset time may have biased the reported event window. Thus, attempts to develop probabilistic DCS models that reproduce BIG292 bimodality are unlikely to result in an improvement in model performance for data outside of the calibration set.

Duke Scholars

Published In

Computers in biology and medicine

DOI

EISSN

1879-0534

ISSN

0010-4825

Publication Date

December 2017

Volume

91

Start / End Page

59 / 68

Related Subject Headings

  • Time Factors
  • Models, Statistical
  • Models, Biological
  • Humans
  • Diving
  • Decompression Sickness
  • Biomedical Research
  • Biomedical Engineering
  • 4601 Applied computing
  • 4203 Health services and systems
 

Citation

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ICMJE
MLA
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King, A. E., Murphy, F. G., & Howle, L. E. (2017). Bimodal decompression sickness onset times are not related to dive type or event severity. Computers in Biology and Medicine, 91, 59–68. https://doi.org/10.1016/j.compbiomed.2017.10.010
King, Amy E., F Gregory Murphy, and Laurens E. Howle. “Bimodal decompression sickness onset times are not related to dive type or event severity.Computers in Biology and Medicine 91 (December 2017): 59–68. https://doi.org/10.1016/j.compbiomed.2017.10.010.
King AE, Murphy FG, Howle LE. Bimodal decompression sickness onset times are not related to dive type or event severity. Computers in biology and medicine. 2017 Dec;91:59–68.
King, Amy E., et al. “Bimodal decompression sickness onset times are not related to dive type or event severity.Computers in Biology and Medicine, vol. 91, Dec. 2017, pp. 59–68. Epmc, doi:10.1016/j.compbiomed.2017.10.010.
King AE, Murphy FG, Howle LE. Bimodal decompression sickness onset times are not related to dive type or event severity. Computers in biology and medicine. 2017 Dec;91:59–68.
Journal cover image

Published In

Computers in biology and medicine

DOI

EISSN

1879-0534

ISSN

0010-4825

Publication Date

December 2017

Volume

91

Start / End Page

59 / 68

Related Subject Headings

  • Time Factors
  • Models, Statistical
  • Models, Biological
  • Humans
  • Diving
  • Decompression Sickness
  • Biomedical Research
  • Biomedical Engineering
  • 4601 Applied computing
  • 4203 Health services and systems