Skip to main content

Implementation of Tuberculosis Intensive Case Finding, Isoniazid Preventive Therapy, and Infection Control ("Three I's") and HIV-Tuberculosis Service Integration in Lower Income Countries.

Publication ,  Journal Article
Charles, MK; Lindegren, ML; Wester, CW; Blevins, M; Sterling, TR; Dung, NT; Dusingize, JC; Avit-Edi, D; Durier, N; Castelnuovo, B; Nakigozi, G ...
Published in: PLoS One
2016

SETTING: World Health Organization advocates for integration of HIV-tuberculosis (TB) services and recommends intensive case finding (ICF), isoniazid preventive therapy (IPT), and infection control ("Three I's") for TB prevention and control among persons living with HIV. OBJECTIVE: To assess the implementation of the "Three I's" of TB-control at HIV treatment sites in lower income countries. DESIGN: Survey conducted between March-July, 2012 at 47 sites in 26 countries: 6 (13%) Asia Pacific, 7 (15%), Caribbean, Central and South America, 5 (10%) Central Africa, 8 (17%) East Africa, 14 (30%) Southern Africa, and 7 (15%) West Africa. RESULTS: ICF using symptom-based screening was performed at 38% of sites; 45% of sites used symptom-screening plus additional diagnostics. IPT at enrollment or ART initiation was implemented in only 17% of sites, with 9% of sites providing IPT to tuberculin-skin-test positive patients. Infection control measures varied: 62% of sites separated smear-positive patients, and healthcare workers used masks at 57% of sites. Only 12 (26%) sites integrated HIV-TB services. Integration was not associated with implementation of TB prevention measures except for IPT provision at enrollment (42% integrated vs. 9% non-integrated; p = 0.03). CONCLUSIONS: Implementation of TB screening, IPT provision, and infection control measures was low and variable across regional HIV treatment sites, regardless of integration status.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2016

Volume

11

Issue

4

Start / End Page

e0153243

Location

United States

Related Subject Headings

  • World Health Organization
  • Tuberculosis
  • South America
  • Poverty
  • Isoniazid
  • Infection Control
  • Humans
  • HIV Infections
  • General Science & Technology
  • Caribbean Region
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Charles, M. K., Lindegren, M. L., Wester, C. W., Blevins, M., Sterling, T. R., Dung, N. T., … International epidemiology Databases to Evaluate AIDS (IeDEA) Collaboration, . (2016). Implementation of Tuberculosis Intensive Case Finding, Isoniazid Preventive Therapy, and Infection Control ("Three I's") and HIV-Tuberculosis Service Integration in Lower Income Countries. PLoS One, 11(4), e0153243. https://doi.org/10.1371/journal.pone.0153243
Charles, M Katherine, Mary Lou Lindegren, C William Wester, Meridith Blevins, Timothy R. Sterling, Nguyen Thi Dung, Jean Claude Dusingize, et al. “Implementation of Tuberculosis Intensive Case Finding, Isoniazid Preventive Therapy, and Infection Control ("Three I's") and HIV-Tuberculosis Service Integration in Lower Income Countries.PLoS One 11, no. 4 (2016): e0153243. https://doi.org/10.1371/journal.pone.0153243.
Charles MK, Lindegren ML, Wester CW, Blevins M, Sterling TR, Dung NT, Dusingize JC, Avit-Edi D, Durier N, Castelnuovo B, Nakigozi G, Cortes CP, Ballif M, Fenner L, International epidemiology Databases to Evaluate AIDS (IeDEA) Collaboration. Implementation of Tuberculosis Intensive Case Finding, Isoniazid Preventive Therapy, and Infection Control ("Three I's") and HIV-Tuberculosis Service Integration in Lower Income Countries. PLoS One. 2016;11(4):e0153243.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2016

Volume

11

Issue

4

Start / End Page

e0153243

Location

United States

Related Subject Headings

  • World Health Organization
  • Tuberculosis
  • South America
  • Poverty
  • Isoniazid
  • Infection Control
  • Humans
  • HIV Infections
  • General Science & Technology
  • Caribbean Region