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Longitudinal Study of Bladder Continence in Patients with Spina Bifida in the National Spina Bifida Patient Registry.

Publication ,  Journal Article
Liu, T; Ouyang, L; Thibadeau, J; Wiener, JS; Routh, JC; Castillo, H; Castillo, J; Freeman, KA; Sawin, KJ; Smith, K; Van Speybroeck, A; Valdez, R
Published in: J Urol
March 2018

PURPOSE: Achieving bladder continence in individuals with spina bifida is a lifetime management goal. We investigated bladder continence status through time and factors associated with this status in patients with spina bifida. MATERIALS AND METHODS: We used National Spina Bifida Patient Registry data collected from 2009 through 2015 and applied generalized estimating equation models to analyze factors associated with bladder continence status. RESULTS: This analysis included 5,250 participants with spina bifida in a large, multi-institutional patient registry who accounted for 12,740 annual clinic visit records during the study period. At last followup mean age was 16.6 years, 22.4% of participants had undergone bladder continence surgery, 92.6% used some form of bladder management and 45.8% reported bladder continence. In a multivariable regression model the likelihood of bladder continence was significantly greater in those who were older, were female, were nonHispanic white, had a nonmyelomeningocele diagnosis, had a lower level of lesion, had a higher mobility level and had private insurance. Continence surgery history and current management were also associated with continence independent of all other factors (adjusted OR and 95% CI 1.9, 1.7-2.1 and 3.8, 3.2-4.6, respectively). The association between bladder management and continence was stronger for those with a myelomeningocele diagnosis (adjusted OR 4.6) than with nonmyelomeningocele (adjusted OR 2.8). CONCLUSIONS: In addition to demographic, social and clinical factors, surgical intervention and bladder management are significantly and independently associated with bladder continence status in individuals with spina bifida. The association between bladder management and continence is stronger in those with myelomeningocele.

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Published In

J Urol

DOI

EISSN

1527-3792

Publication Date

March 2018

Volume

199

Issue

3

Start / End Page

837 / 843

Location

United States

Related Subject Headings

  • Young Adult
  • Urology & Nephrology
  • Urination
  • Urinary Bladder, Neurogenic
  • United States
  • Time Factors
  • Spinal Dysraphism
  • Retrospective Studies
  • Registries
  • Prognosis
 

Citation

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ICMJE
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Liu, T., Ouyang, L., Thibadeau, J., Wiener, J. S., Routh, J. C., Castillo, H., … Valdez, R. (2018). Longitudinal Study of Bladder Continence in Patients with Spina Bifida in the National Spina Bifida Patient Registry. J Urol, 199(3), 837–843. https://doi.org/10.1016/j.juro.2017.11.048
Liu, Tiebin, Lijing Ouyang, Judy Thibadeau, John S. Wiener, Jonathan C. Routh, Heidi Castillo, Jonathan Castillo, et al. “Longitudinal Study of Bladder Continence in Patients with Spina Bifida in the National Spina Bifida Patient Registry.J Urol 199, no. 3 (March 2018): 837–43. https://doi.org/10.1016/j.juro.2017.11.048.
Liu T, Ouyang L, Thibadeau J, Wiener JS, Routh JC, Castillo H, et al. Longitudinal Study of Bladder Continence in Patients with Spina Bifida in the National Spina Bifida Patient Registry. J Urol. 2018 Mar;199(3):837–43.
Liu, Tiebin, et al. “Longitudinal Study of Bladder Continence in Patients with Spina Bifida in the National Spina Bifida Patient Registry.J Urol, vol. 199, no. 3, Mar. 2018, pp. 837–43. Pubmed, doi:10.1016/j.juro.2017.11.048.
Liu T, Ouyang L, Thibadeau J, Wiener JS, Routh JC, Castillo H, Castillo J, Freeman KA, Sawin KJ, Smith K, Van Speybroeck A, Valdez R. Longitudinal Study of Bladder Continence in Patients with Spina Bifida in the National Spina Bifida Patient Registry. J Urol. 2018 Mar;199(3):837–843.
Journal cover image

Published In

J Urol

DOI

EISSN

1527-3792

Publication Date

March 2018

Volume

199

Issue

3

Start / End Page

837 / 843

Location

United States

Related Subject Headings

  • Young Adult
  • Urology & Nephrology
  • Urination
  • Urinary Bladder, Neurogenic
  • United States
  • Time Factors
  • Spinal Dysraphism
  • Retrospective Studies
  • Registries
  • Prognosis