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Pre-diagnosis health-related quality of life, surgery, and survival in women with advanced epithelial ovarian cancer: A SEER-MHOS study.

Publication ,  Journal Article
Doll, KM; Pinheiro, LC; Reeve, BB
Published in: Gynecol Oncol
February 2017

OBJECTIVE: Health-related quality of life (HRQOL) has been found to be associated with overall survival in women with ovarian cancer. However, previous studies assessed HRQOL after surgery within clinical trial populations only. The study goal was to determine the association of pre-cancer diagnosis HRQOL with the likelihood of receiving surgery and with overall survival in a national, population-based cohort of older women with advanced ovarian cancer. METHODS: The Surveillance, Epidemiology, and End Results (SEER)-Medicare Health Outcomes Survey (MHOS) database was queried to identify 374 women aged 65years and older with advanced stage epithelial ovarian cancer from 1998 to 2011. Responses to the Short Form 36 (SF-36) and Veterans-RAND-12 (VR-12), two single-item global health questions, and Activities of Daily Living (ADLs) were abstracted. Multivariable models were used to quantify associations of HRQOL and ADL assessments with surgery and overall survival, adjusted for demographic and clinical characteristics. RESULTS: Of 374 women with a HRQOL assessment prior to diagnosis, 199 (53%) underwent surgery. Increases in physical and mental HRQOL domains were significantly associated with receipt of surgery. The relationship between HRQOL domains and overall survival were not statistically significant. For ADLs, only difficulty in toilet use was significantly associated with survival. CONCLUSION: In this population-based sample of older women with advanced epithelial ovarian cancer, pre-diagnosis HRQOL was predictive of receiving surgery, but not of overall survival.

Duke Scholars

Published In

Gynecol Oncol

DOI

EISSN

1095-6859

Publication Date

February 2017

Volume

144

Issue

2

Start / End Page

348 / 353

Location

United States

Related Subject Headings

  • United States
  • SEER Program
  • Quality of Life
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasms, Glandular and Epithelial
  • Medicare
  • Humans
  • Health Surveys
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Doll, K. M., Pinheiro, L. C., & Reeve, B. B. (2017). Pre-diagnosis health-related quality of life, surgery, and survival in women with advanced epithelial ovarian cancer: A SEER-MHOS study. Gynecol Oncol, 144(2), 348–353. https://doi.org/10.1016/j.ygyno.2016.12.005
Doll, Kemi M., Laura C. Pinheiro, and Bryce B. Reeve. “Pre-diagnosis health-related quality of life, surgery, and survival in women with advanced epithelial ovarian cancer: A SEER-MHOS study.Gynecol Oncol 144, no. 2 (February 2017): 348–53. https://doi.org/10.1016/j.ygyno.2016.12.005.
Doll, Kemi M., et al. “Pre-diagnosis health-related quality of life, surgery, and survival in women with advanced epithelial ovarian cancer: A SEER-MHOS study.Gynecol Oncol, vol. 144, no. 2, Feb. 2017, pp. 348–53. Pubmed, doi:10.1016/j.ygyno.2016.12.005.
Journal cover image

Published In

Gynecol Oncol

DOI

EISSN

1095-6859

Publication Date

February 2017

Volume

144

Issue

2

Start / End Page

348 / 353

Location

United States

Related Subject Headings

  • United States
  • SEER Program
  • Quality of Life
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasms, Glandular and Epithelial
  • Medicare
  • Humans
  • Health Surveys
  • Female