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The challenge of measuring intra-individual change in fatigue during cancer treatment.

Publication ,  Journal Article
Moinpour, CM; Donaldson, GW; Davis, KM; Potosky, AL; Jensen, RE; Gralow, JR; Back, AL; Hwang, JJ; Yoon, J; Bernard, DL; Loeffler, DR; Hays, RD ...
Published in: Qual Life Res
February 2017

PURPOSE: To evaluate how well three different patient-reported outcomes (PROs) measure individual change. METHODS: Two hundred and fourteen patients (from two sites) initiating first or new chemotherapy for any stage of breast or gastrointestinal cancer participated. The 13-item FACIT Fatigue scale, a 7-item PROMIS® Fatigue Short Form (PROMIS 7a), and the PROMIS® Fatigue computer adaptive test (CAT) were administered monthly online for 6 months. Reliability of measured change was defined, under a population mixed effects model, as the ratio of estimated systematic variance in rate of change to the estimated total variance of measured individual differences in rate of change. Precision of individual measured change, the standard error of measurement of change, was given by the square root of the rate-of-change sampling variance. Linear and quadratic models were examined up to 3 and up to 6 months. RESULTS: A linear model for measured change showed the following by 6 and 3 months, respectively: PROMIS CAT (0.363 and 0.342); PROMIS SF (0.408 and 0.533); FACIT (0.459 and 0.473). Quadratic models offered no noteworthy improvement over linear models. Both reliability and precision results demonstrate the need to improve the measurement of intra-individual change. CONCLUSIONS: These results illustrate the challenge of reliably measuring individual change in fatigue with a level of confidence required for intervention. Optimizing clinically useful measurement of intra-individual differences over time continues to pose a challenge for PROs.

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Published In

Qual Life Res

DOI

EISSN

1573-2649

Publication Date

February 2017

Volume

26

Issue

2

Start / End Page

259 / 271

Location

Netherlands

Related Subject Headings

  • Surveys and Questionnaires
  • Quality of Life
  • Patient Reported Outcome Measures
  • Neoplasms
  • Middle Aged
  • Humans
  • Health Policy & Services
  • Female
  • Fatigue
  • 44 Human society
 

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Moinpour, C. M., Donaldson, G. W., Davis, K. M., Potosky, A. L., Jensen, R. E., Gralow, J. R., … Cella, D. (2017). The challenge of measuring intra-individual change in fatigue during cancer treatment. Qual Life Res, 26(2), 259–271. https://doi.org/10.1007/s11136-016-1372-9
Moinpour, Carol M., Gary W. Donaldson, Kimberly M. Davis, Arnold L. Potosky, Roxanne E. Jensen, Julie R. Gralow, Anthony L. Back, et al. “The challenge of measuring intra-individual change in fatigue during cancer treatment.Qual Life Res 26, no. 2 (February 2017): 259–71. https://doi.org/10.1007/s11136-016-1372-9.
Moinpour CM, Donaldson GW, Davis KM, Potosky AL, Jensen RE, Gralow JR, et al. The challenge of measuring intra-individual change in fatigue during cancer treatment. Qual Life Res. 2017 Feb;26(2):259–71.
Moinpour, Carol M., et al. “The challenge of measuring intra-individual change in fatigue during cancer treatment.Qual Life Res, vol. 26, no. 2, Feb. 2017, pp. 259–71. Pubmed, doi:10.1007/s11136-016-1372-9.
Moinpour CM, Donaldson GW, Davis KM, Potosky AL, Jensen RE, Gralow JR, Back AL, Hwang JJ, Yoon J, Bernard DL, Loeffler DR, Rothrock NE, Hays RD, Reeve BB, Smith AW, Hahn EA, Cella D. The challenge of measuring intra-individual change in fatigue during cancer treatment. Qual Life Res. 2017 Feb;26(2):259–271.
Journal cover image

Published In

Qual Life Res

DOI

EISSN

1573-2649

Publication Date

February 2017

Volume

26

Issue

2

Start / End Page

259 / 271

Location

Netherlands

Related Subject Headings

  • Surveys and Questionnaires
  • Quality of Life
  • Patient Reported Outcome Measures
  • Neoplasms
  • Middle Aged
  • Humans
  • Health Policy & Services
  • Female
  • Fatigue
  • 44 Human society