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The Added Value of Analyzing Pooled Health-Related Quality of Life Data: A Review of the EORTC PROBE Initiative.

Publication ,  Journal Article
Zikos, E; Coens, C; Quinten, C; Ediebah, DE; Martinelli, F; Ghislain, I; King, MT; Gotay, C; Ringash, J; Velikova, G; Reeve, BB; Greimel, E ...
Published in: J Natl Cancer Inst
May 2016

BACKGROUND: The European Organisation for Research and Treatment of Cancer (EORTC) Patient-Reported Outcomes and Behavioural Evidence (PROBE) initiative was established to investigate critical topics to better understand health-related quality of life (HRQOL) of cancer patients and to educate clinicians, policy makers, and healthcare providers. METHODS: The aim of this paper is to review the major research outcomes of the pooled analysis of HRQOL data along with the clinical data. We identified 30 pooled EORTC randomized controlled trials (RCTs), 18 NCIC-Clinical Trials Group RCTs, and two German Ovarian Cancer Study Group RCTs, all using the EORTC QLQ-C30. All statistical tests were two-sided. RESULTS: Evidence was found that HRQOL data can offer prognostic information beyond clinical measures and improve prognostic accuracy in cancer RCTs (by 5.9%-8.3%). Moreover, models that considered both patient- and clinician-reported scores gained more prognostic overall survival accuracy for fatigue (P < .001), vomiting (P = .01), nausea (P < .001), and constipation (P = .01). Greater understanding of the association between symptom and/or functioning scales was developed by identifying physical, psychological, and gastrointestinal clusters. Additionally, minimally important differences in interpreting HRQOL changes for improvement and deterioration were found to vary across different patient populations and disease stages. Finally, HRQOL scores are statistically significantly affected by deviations from the intended time point at which the questionnaire is completed. CONCLUSIONS: The use of existing pooled data shows that it is possible to learn about general aspects of cancer HRQOL and methodology. Our work shows that setting up international pooled datasets holds great promise for understanding patients' unmet psychosocial needs and calls for additional empirical investigation to improve clinical care and understand cancer through retrospective HRQOL analyses.

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Published In

J Natl Cancer Inst

DOI

EISSN

1460-2105

Publication Date

May 2016

Volume

108

Issue

5

Location

United States

Related Subject Headings

  • Vomiting
  • Treatment Outcome
  • Survival Analysis
  • Self Report
  • Research Design
  • Randomized Controlled Trials as Topic
  • Quality of Life
  • Prognosis
  • Patient Satisfaction
  • Oncology & Carcinogenesis
 

Citation

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Zikos, E., Coens, C., Quinten, C., Ediebah, D. E., Martinelli, F., Ghislain, I., … EORTC PROBE, . (2016). The Added Value of Analyzing Pooled Health-Related Quality of Life Data: A Review of the EORTC PROBE Initiative. J Natl Cancer Inst, 108(5). https://doi.org/10.1093/jnci/djv391
Zikos, Efstathios, Corneel Coens, Chantal Quinten, Divine E. Ediebah, Francesca Martinelli, Irina Ghislain, Madeleine T. King, et al. “The Added Value of Analyzing Pooled Health-Related Quality of Life Data: A Review of the EORTC PROBE Initiative.J Natl Cancer Inst 108, no. 5 (May 2016). https://doi.org/10.1093/jnci/djv391.
Zikos E, Coens C, Quinten C, Ediebah DE, Martinelli F, Ghislain I, et al. The Added Value of Analyzing Pooled Health-Related Quality of Life Data: A Review of the EORTC PROBE Initiative. J Natl Cancer Inst. 2016 May;108(5).
Zikos, Efstathios, et al. “The Added Value of Analyzing Pooled Health-Related Quality of Life Data: A Review of the EORTC PROBE Initiative.J Natl Cancer Inst, vol. 108, no. 5, May 2016. Pubmed, doi:10.1093/jnci/djv391.
Zikos E, Coens C, Quinten C, Ediebah DE, Martinelli F, Ghislain I, King MT, Gotay C, Ringash J, Velikova G, Reeve BB, Greimel E, Cleeland CS, Flechtner H, Taphoorn MJB, Weis J, Schmucker-von Koch J, Sprangers MAG, Bottomley A, EORTC PROBE. The Added Value of Analyzing Pooled Health-Related Quality of Life Data: A Review of the EORTC PROBE Initiative. J Natl Cancer Inst. 2016 May;108(5).
Journal cover image

Published In

J Natl Cancer Inst

DOI

EISSN

1460-2105

Publication Date

May 2016

Volume

108

Issue

5

Location

United States

Related Subject Headings

  • Vomiting
  • Treatment Outcome
  • Survival Analysis
  • Self Report
  • Research Design
  • Randomized Controlled Trials as Topic
  • Quality of Life
  • Prognosis
  • Patient Satisfaction
  • Oncology & Carcinogenesis