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The effects of age on health-related quality of life in cancer populations: A pooled analysis of randomized controlled trials using the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 involving 6024 cancer patients.

Publication ,  Journal Article
Quinten, C; Coens, C; Ghislain, I; Zikos, E; Sprangers, MAG; Ringash, J; Martinelli, F; Ediebah, DE; Maringwa, J; Reeve, BB; Greimel, E ...
Published in: Eur J Cancer
December 2015

BACKGROUND: Cancer incidence increases exponentially with advancing age, cancer patients live longer than in the past, and many new treatments focus on stabilizing disease and HRQOL. The objective of this study is to examine how cancer affects patients' HRQOL and whether their HRQOL is age-dependent. METHODS: Data from 25 EORTC randomized controlled trials was pooled. EORTC QLQ-C30 mean scores for the cancer cohort and five general population cohorts were compared to assess the impact of cancer on patients' HRQOL. Within the cancer cohort, multiple linear regressions (two-sided level P-value = 0.05 adjusted for multiple testing.) were used to investigate the association between age and HRQOL, adjusted for gender, WHO performance status (PS), distant metastasis and stratified by cancer site. A difference of 10 points on the 0-100 scale was considered clinically important. RESULTS: Cancer patients generally have worse HRQOL compared to the general population, but the specific HRQOL domains impaired vary with age. When comparing the cancer versus the general population, young cancer patients had worse financial problems, social and role functioning, while the older cancer groups had more appetite loss. Within the cancer cohort, HRQOL was worse with increasing age for physical functioning and constipation, and better with increasing age for social functioning, insomnia and financial problems (all p < 0.05). CONCLUSION: HRQOL is impaired in cancer patients compared to the general population, but the impact on specific HRQOL domains varies by age. Within the cancer population, some HRQOL components improve with age while others deteriorate. Optimal care for older cancer patients should target HRQOL domains most relevant to this population.

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Published In

Eur J Cancer

DOI

EISSN

1879-0852

Publication Date

December 2015

Volume

51

Issue

18

Start / End Page

2808 / 2819

Location

England

Related Subject Headings

  • Young Adult
  • Time Factors
  • Surveys and Questionnaires
  • South Africa
  • Risk Factors
  • Randomized Controlled Trials as Topic
  • Quality of Life
  • Prognosis
  • Oncology & Carcinogenesis
  • North America
 

Citation

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Quinten, C., Coens, C., Ghislain, I., Zikos, E., Sprangers, M. A. G., Ringash, J., … EORTC Clinical Groups, . (2015). The effects of age on health-related quality of life in cancer populations: A pooled analysis of randomized controlled trials using the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 involving 6024 cancer patients. Eur J Cancer, 51(18), 2808–2819. https://doi.org/10.1016/j.ejca.2015.08.027
Quinten, Chantal, Corneel Coens, Irina Ghislain, Efstathios Zikos, Mirjam A. G. Sprangers, Jolie Ringash, Francesca Martinelli, et al. “The effects of age on health-related quality of life in cancer populations: A pooled analysis of randomized controlled trials using the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 involving 6024 cancer patients.Eur J Cancer 51, no. 18 (December 2015): 2808–19. https://doi.org/10.1016/j.ejca.2015.08.027.
Quinten C, Coens C, Ghislain I, Zikos E, Sprangers MAG, Ringash J, Martinelli F, Ediebah DE, Maringwa J, Reeve BB, Greimel E, King MT, Bjordal K, Flechtner H-H, Schmucker-Von Koch J, Taphoorn MJB, Weis J, Wildiers H, Velikova G, Bottomley A, PROBE, EORTC Clinical Groups. The effects of age on health-related quality of life in cancer populations: A pooled analysis of randomized controlled trials using the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 involving 6024 cancer patients. Eur J Cancer. 2015 Dec;51(18):2808–2819.
Journal cover image

Published In

Eur J Cancer

DOI

EISSN

1879-0852

Publication Date

December 2015

Volume

51

Issue

18

Start / End Page

2808 / 2819

Location

England

Related Subject Headings

  • Young Adult
  • Time Factors
  • Surveys and Questionnaires
  • South Africa
  • Risk Factors
  • Randomized Controlled Trials as Topic
  • Quality of Life
  • Prognosis
  • Oncology & Carcinogenesis
  • North America