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Recommendations for high-priority research on cancer-related fatigue in children and adults.

Publication ,  Journal Article
Barsevick, AM; Irwin, MR; Hinds, P; Miller, A; Berger, A; Jacobsen, P; Ancoli-Israel, S; Reeve, BB; Mustian, K; O'Mara, A; Lai, J-S; Fisch, M ...
Published in: J Natl Cancer Inst
October 2, 2013

Over the past decades, some scientific progress has been made in understanding and treating cancer-related fatigue (CRF). However, three major problems have limited further progress: lack of agreement about measurement, inadequate understanding of the underlying biology, and problems in the conduct of clinical trials for CRF. This commentary reports the recommendations of a National Cancer Institute Clinical Trials Planning Meeting and an ongoing National Cancer Institute working group to address these problems so that high-priority research and clinical trials can be conducted to advance the science of CRF and its treatment. Recommendations to address measurement issues included revising the current case definition to reflect more rigorous criteria, adopting the Patient Reported Outcomes Measurement Information System fatigue scales as standard measures of CRF, and linking legacy measures to the scales. With regard to the biology of CRF, the group identified the need for longitudinal research to examine biobehavioral mechanisms underlying CRF and testing mechanistic hypotheses within the context of intervention research. To address clinical trial issues, recommendations included using only placebo-controlled trial designs. setting eligibility to minimize sample heterogeneity or enable subgroup analysis, establishing a CRF severity threshold for participation in clinical trials, conducting dissemination trials of efficacious interventions (such as exercise), and combining nonpharmacologic and pharmacologic interventions to exploit the potential synergy between these approaches. Accomplishing these goals has the potential to advance the science of CRF and improve the clinical management of this troubling symptom.

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Published In

J Natl Cancer Inst

DOI

EISSN

1460-2105

Publication Date

October 2, 2013

Volume

105

Issue

19

Start / End Page

1432 / 1440

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Sleep Deprivation
  • Risk Factors
  • Research Design
  • Patient Satisfaction
  • Oncology & Carcinogenesis
  • Neoplasms
  • National Cancer Institute (U.S.)
  • Motor Activity
 

Citation

APA
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Barsevick, A. M., Irwin, M. R., Hinds, P., Miller, A., Berger, A., Jacobsen, P., … National Cancer Institute Clinical Trials Planning Meeting, . (2013). Recommendations for high-priority research on cancer-related fatigue in children and adults. J Natl Cancer Inst, 105(19), 1432–1440. https://doi.org/10.1093/jnci/djt242
Barsevick, Andrea M., Michael R. Irwin, Pamela Hinds, Andrew Miller, Ann Berger, Paul Jacobsen, Sonia Ancoli-Israel, et al. “Recommendations for high-priority research on cancer-related fatigue in children and adults.J Natl Cancer Inst 105, no. 19 (October 2, 2013): 1432–40. https://doi.org/10.1093/jnci/djt242.
Barsevick AM, Irwin MR, Hinds P, Miller A, Berger A, Jacobsen P, et al. Recommendations for high-priority research on cancer-related fatigue in children and adults. J Natl Cancer Inst. 2013 Oct 2;105(19):1432–40.
Barsevick, Andrea M., et al. “Recommendations for high-priority research on cancer-related fatigue in children and adults.J Natl Cancer Inst, vol. 105, no. 19, Oct. 2013, pp. 1432–40. Pubmed, doi:10.1093/jnci/djt242.
Barsevick AM, Irwin MR, Hinds P, Miller A, Berger A, Jacobsen P, Ancoli-Israel S, Reeve BB, Mustian K, O’Mara A, Lai J-S, Fisch M, Cella D, National Cancer Institute Clinical Trials Planning Meeting. Recommendations for high-priority research on cancer-related fatigue in children and adults. J Natl Cancer Inst. 2013 Oct 2;105(19):1432–1440.
Journal cover image

Published In

J Natl Cancer Inst

DOI

EISSN

1460-2105

Publication Date

October 2, 2013

Volume

105

Issue

19

Start / End Page

1432 / 1440

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Sleep Deprivation
  • Risk Factors
  • Research Design
  • Patient Satisfaction
  • Oncology & Carcinogenesis
  • Neoplasms
  • National Cancer Institute (U.S.)
  • Motor Activity