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Impact of cancer on health-related quality of life of older Americans.

Publication ,  Journal Article
Reeve, BB; Potosky, AL; Smith, AW; Han, PK; Hays, RD; Davis, WW; Arora, NK; Haffer, SC; Clauser, SB
Published in: J Natl Cancer Inst
June 16, 2009

BACKGROUND: The impact of cancer on health-related quality of life (HRQOL) is poorly understood because of the lack of baseline HRQOL status before cancer diagnosis. To our knowledge, this is the first population-based study to quantify the nature and extent of HRQOL changes from before to after cancer diagnosis for nine types of cancer patients and to compare their health with individuals without cancer. METHODS: The Surveillance, Epidemiology, and End Results cancer registry data were linked with the Medicare Health Outcomes Survey (MHOS) data; data were collected from Medicare beneficiaries who were aged 65 years and older from 1998 through 2003. Cancer patients (n = 1432; with prostate, breast, colorectal, lung, bladder, endometrial, or kidney cancers; melanoma; or non-Hodgkin lymphoma [NHL]) were selected whose first cancer diagnosis occurred between their baseline and follow-up MHOS assessments. Control subjects without cancer (n = 7160) were matched to cancer patients by use of propensity scores that were estimated from demographics and comorbid medical conditions. Analysis of covariance models were used to estimate changes in HRQOL as assessed with the Medical Outcomes Study Short Form-36 survey (mean score = 50, SD = 10). All statistical tests were two-sided. RESULTS: Patients with all cancer types (except melanoma and endometrial cancer) reported statistically significant declines in physical health (mean scores: prostate cancer = -3.4, 95% confidence interval [CI] = -2.5 to -4.2; breast cancer = -3.5, 95% CI = -2.5 to -4.5; bladder cancer = -4.3, 95% CI = -2.5 to -6.1; colorectal cancer = -4.4, 95% CI = -3.3 to -5.5; kidney cancer = -5.7, 95% CI = -3.2 to -8.2; NHL = -6.7, 95% CI = -4.4 to -9.1; and lung cancer = -7.5, 95% CI = -5.9 to -9.2) compared with the control subjects (mean score = -1.8, 95% CI = -1.6 to -2.0) (all P < .05). However, only lung (mean score = -5.4, 95% CI = -3.5 to -7.2), colorectal (mean score = -3.5, 95% CI = -2.2 to -4.7), and prostate (mean score = -2.8, 95% CI = -1.8 to -3.7) cancer patients showed statistically significant decreases in mental health relative to the mean change of the control subjects (mean score = -1.2, 95% CI = -0.9 to -1.4) (all P < .05). CONCLUSION: These findings provide validation of the specific deleterious effects of cancer on HRQOL and an evidence base for future research and clinical interventions aimed at understanding and remediating these effects.

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Published In

J Natl Cancer Inst

DOI

EISSN

1460-2105

Publication Date

June 16, 2009

Volume

101

Issue

12

Start / End Page

860 / 868

Location

United States

Related Subject Headings

  • United States
  • Severity of Illness Index
  • SEER Program
  • Quality of Life
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Neoplasms
  • Mental Health
  • Medicare
  • Medical Record Linkage
 

Citation

APA
Chicago
ICMJE
MLA
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Reeve, B. B., Potosky, A. L., Smith, A. W., Han, P. K., Hays, R. D., Davis, W. W., … Clauser, S. B. (2009). Impact of cancer on health-related quality of life of older Americans. J Natl Cancer Inst, 101(12), 860–868. https://doi.org/10.1093/jnci/djp123
Reeve, Bryce B., Arnold L. Potosky, Ashley Wilder Smith, Paul K. Han, Ron D. Hays, William W. Davis, Neeraj K. Arora, Samuel C. Haffer, and Steven B. Clauser. “Impact of cancer on health-related quality of life of older Americans.J Natl Cancer Inst 101, no. 12 (June 16, 2009): 860–68. https://doi.org/10.1093/jnci/djp123.
Reeve BB, Potosky AL, Smith AW, Han PK, Hays RD, Davis WW, et al. Impact of cancer on health-related quality of life of older Americans. J Natl Cancer Inst. 2009 Jun 16;101(12):860–8.
Reeve, Bryce B., et al. “Impact of cancer on health-related quality of life of older Americans.J Natl Cancer Inst, vol. 101, no. 12, June 2009, pp. 860–68. Pubmed, doi:10.1093/jnci/djp123.
Reeve BB, Potosky AL, Smith AW, Han PK, Hays RD, Davis WW, Arora NK, Haffer SC, Clauser SB. Impact of cancer on health-related quality of life of older Americans. J Natl Cancer Inst. 2009 Jun 16;101(12):860–868.
Journal cover image

Published In

J Natl Cancer Inst

DOI

EISSN

1460-2105

Publication Date

June 16, 2009

Volume

101

Issue

12

Start / End Page

860 / 868

Location

United States

Related Subject Headings

  • United States
  • Severity of Illness Index
  • SEER Program
  • Quality of Life
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Neoplasms
  • Mental Health
  • Medicare
  • Medical Record Linkage