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Nighttime blood pressure dipping in young adults and coronary artery calcium 10-15 years later: the coronary artery risk development in young adults study.

Publication ,  Journal Article
Viera, AJ; Lin, F-C; Hinderliter, AL; Shimbo, D; Person, SD; Pletcher, MJ; Jacobs, DR
Published in: Hypertension
June 2012

Nighttime blood pressure (BP) dipping can be quantified as the ratio of mean nighttime (sleep) BP to mean daytime (awake) BP. People whose dipping ratio is ≥ 0.90 have been referred to as nondippers, and nondipping is associated with cardiovascular disease events. We examined the relationship between systolic nighttime BP dipping in young adults and the presence of coronary artery calcium (CAC) 10 to 15 years later using data from the ambulatory BP monitoring substudy of the Coronary Artery Risk Development in Young Adults Study. Among 239 participants with adequate measures of both nighttime and daytime readings and coronary artery calcium, the systolic BP dipping ratio ranged from 0.72 to 1.24 (mean, 0.88; SD, 0.06), and CAC was present 10 to 15 years later in 54 participants (22.6%). Compared with those whose systolic BP dipping ratio ranged from 0.88 to 0.92 (quartile 3), the 57 participants (23.9%) with less pronounced or absent dipping (ratio, 0.92-1.24; quartile 4) had an unadjusted odds ratio of 4.08 (95% CI, 1.48-11.2) for the presence of CAC. The 60 participants (25.1%) with a more pronounced dipping (ratio, 0.72-0.85; quartile 1) also had greater odds for presence of CAC (odds ratio, 4.76 [95% CI, 1.76-12.9]). When modeled as a continuous predictor, a U-shaped relationship between systolic BP dipping ratio and future CAC was apparent and persisted after adjustment for multiple potential confounders (P<0.001 for quadratic term). Both failure of systolic BP to dip sufficiently and "overdipping" during nighttime may be associated with future subclinical coronary atherosclerosis.

Duke Scholars

Published In

Hypertension

DOI

EISSN

1524-4563

Publication Date

June 2012

Volume

59

Issue

6

Start / End Page

1157 / 1163

Location

United States

Related Subject Headings

  • Young Adult
  • Time Factors
  • Systole
  • Risk Factors
  • Risk Assessment
  • Multivariate Analysis
  • Male
  • Hypertension
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Viera, A. J., Lin, F.-C., Hinderliter, A. L., Shimbo, D., Person, S. D., Pletcher, M. J., & Jacobs, D. R. (2012). Nighttime blood pressure dipping in young adults and coronary artery calcium 10-15 years later: the coronary artery risk development in young adults study. Hypertension, 59(6), 1157–1163. https://doi.org/10.1161/HYPERTENSIONAHA.112.191536
Viera, Anthony J., Feng-Chang Lin, Alan L. Hinderliter, Daichi Shimbo, Sharina D. Person, Mark J. Pletcher, and David R. Jacobs. “Nighttime blood pressure dipping in young adults and coronary artery calcium 10-15 years later: the coronary artery risk development in young adults study.Hypertension 59, no. 6 (June 2012): 1157–63. https://doi.org/10.1161/HYPERTENSIONAHA.112.191536.
Viera AJ, Lin F-C, Hinderliter AL, Shimbo D, Person SD, Pletcher MJ, et al. Nighttime blood pressure dipping in young adults and coronary artery calcium 10-15 years later: the coronary artery risk development in young adults study. Hypertension. 2012 Jun;59(6):1157–63.
Viera, Anthony J., et al. “Nighttime blood pressure dipping in young adults and coronary artery calcium 10-15 years later: the coronary artery risk development in young adults study.Hypertension, vol. 59, no. 6, June 2012, pp. 1157–63. Pubmed, doi:10.1161/HYPERTENSIONAHA.112.191536.
Viera AJ, Lin F-C, Hinderliter AL, Shimbo D, Person SD, Pletcher MJ, Jacobs DR. Nighttime blood pressure dipping in young adults and coronary artery calcium 10-15 years later: the coronary artery risk development in young adults study. Hypertension. 2012 Jun;59(6):1157–1163.

Published In

Hypertension

DOI

EISSN

1524-4563

Publication Date

June 2012

Volume

59

Issue

6

Start / End Page

1157 / 1163

Location

United States

Related Subject Headings

  • Young Adult
  • Time Factors
  • Systole
  • Risk Factors
  • Risk Assessment
  • Multivariate Analysis
  • Male
  • Hypertension
  • Humans
  • Female