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Temporal changes in retinal vascular parameters associated with successful panretinal photocoagulation in proliferative diabetic retinopathy: A prospective clinical interventional study.

Publication ,  Journal Article
Torp, TL; Kawasaki, R; Wong, TY; Peto, T; Grauslund, J
Published in: Acta Ophthalmol
June 2018

PURPOSE: We aimed to investigate changes in retinal vascular geometry over time after panretinal photocoagulation (PRP) in patients with proliferative diabetic retinopathy (PDR). METHODS: Thirty-seven eyes with PDR were included. Wide-field fluorescein angiography (Optomap, Optos PLC., Dunfermline, Scotland, UK) was used to diagnose PDR at baseline and to assess activity at follow-up month three and six. At each time-point, a trained grader measured retinal vessel geometry on optic disc (OD) centred images using semiautomated software (SIVA, Singapore I Vessel Assessment, National University of Singapore, Singapore) according to a standardized protocol. RESULTS: At baseline, the mean age and duration of diabetes were 52.8 and 22.3 years, and 65% were male. Mean HbA1c was 69.9 mmol/mol, and blood pressure was 155/84 mmHg. Of the 37 eyes with PDR, eight (22%) eyes had progression at month three and 13 (35%) progressed over six months. Baseline characteristics, including age, sex, duration of diabetes, HbA1c, blood pressure, vessel geometric variables and total amount of laser energy delivered did not differ by progression status. However, compared to patients with progression of PDR, patients with favourable treatment outcome had alterations in the retinal arteriolar structures from baseline to month six (calibre, 154.3 μm versus 159.5 μm, p = 0.04, tortuosity 1.12 versus 1.10, p = 0.04) and in venular structures from baseline to month three (fractal dimension 1.490 versus 1.499, p = 0.04, branching coefficient (BC) 1.32 versus 1.37, p = 0.01). CONCLUSION: In patients with PDR, successful PRP leads to alterations in the retinal vascular structure. However, baseline retinal vascular geometry characteristics did not predict treatment outcome.

Duke Scholars

Published In

Acta Ophthalmol

DOI

EISSN

1755-3768

Publication Date

June 2018

Volume

96

Issue

4

Start / End Page

405 / 410

Location

England

Related Subject Headings

  • Tomography, Optical Coherence
  • Retinal Vessels
  • Retina
  • Prospective Studies
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Laser Coagulation
  • Humans
  • Fundus Oculi
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Torp, T. L., Kawasaki, R., Wong, T. Y., Peto, T., & Grauslund, J. (2018). Temporal changes in retinal vascular parameters associated with successful panretinal photocoagulation in proliferative diabetic retinopathy: A prospective clinical interventional study. Acta Ophthalmol, 96(4), 405–410. https://doi.org/10.1111/aos.13617
Torp, Thomas Lee, Ryo Kawasaki, Tien Yin Wong, Tunde Peto, and Jakob Grauslund. “Temporal changes in retinal vascular parameters associated with successful panretinal photocoagulation in proliferative diabetic retinopathy: A prospective clinical interventional study.Acta Ophthalmol 96, no. 4 (June 2018): 405–10. https://doi.org/10.1111/aos.13617.
Journal cover image

Published In

Acta Ophthalmol

DOI

EISSN

1755-3768

Publication Date

June 2018

Volume

96

Issue

4

Start / End Page

405 / 410

Location

England

Related Subject Headings

  • Tomography, Optical Coherence
  • Retinal Vessels
  • Retina
  • Prospective Studies
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Laser Coagulation
  • Humans
  • Fundus Oculi