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Effect of hepatic artery flow on bile secretory function after cold ischemia.

Publication ,  Journal Article
Foley, DP; Ricciardi, R; Traylor, AN; McLaughlin, TJ; Donohue, SE; Wheeler, SM; Meyers, WC; Quarfordt, SH
Published in: Am J Transplant
February 2003

These studies evaluated the influence of hepatic arterial flow on biliary secretion after cold ischemia. Preparation of livers for transplantation or hepatic support impairs biliary secretion. The earliest indication of cold preservation injury during reperfusion is circulatory function. Arterial flow at this time may be critical for bile secretion. Porcine livers were isolated, maintained at 4 degrees for 2 h and connected in an extracorporeal circuit to an anesthetized normal pig. The extracorporeal livers were perfused either by both the hepatic artery and portal vein (dual) or by the portal vein alone (single). Incremental doses of sodium taurocholate were infused into the portal vein of both the dual and single perfused livers, and the bile secretion was compared. Most endogenous bile acids are lost during hepatic isolation. After supplementation, the biliary secretion of phosphatidyl choline and cholesterol was significantly better in the dual than single vessel-perfused livers; however, no difference was seen in bilirubin output. Single perfused livers were completely unable to increase biliary cholesterol in response to bile acid. The dependence of bile cholesterol secretion on arterial flow indicates the importance of this flow to the detoxification of compounds dependent on phosphatidyl choline transport during early transplantation.

Duke Scholars

Published In

Am J Transplant

DOI

ISSN

1600-6135

Publication Date

February 2003

Volume

3

Issue

2

Start / End Page

148 / 155

Location

United States

Related Subject Headings

  • Tissue Survival
  • Taurocholic Acid
  • Swine
  • Surgery
  • Reperfusion Injury
  • Liver Transplantation
  • Liver
  • Ischemia
  • Hepatic Artery
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Foley, D. P., Ricciardi, R., Traylor, A. N., McLaughlin, T. J., Donohue, S. E., Wheeler, S. M., … Quarfordt, S. H. (2003). Effect of hepatic artery flow on bile secretory function after cold ischemia. Am J Transplant, 3(2), 148–155. https://doi.org/10.1034/j.1600-6143.2003.00008.x
Foley, David P., Rocco Ricciardi, Angela N. Traylor, Thomas J. McLaughlin, Susan E. Donohue, Suzanne M. Wheeler, William C. Meyers, and Steven H. Quarfordt. “Effect of hepatic artery flow on bile secretory function after cold ischemia.Am J Transplant 3, no. 2 (February 2003): 148–55. https://doi.org/10.1034/j.1600-6143.2003.00008.x.
Foley DP, Ricciardi R, Traylor AN, McLaughlin TJ, Donohue SE, Wheeler SM, et al. Effect of hepatic artery flow on bile secretory function after cold ischemia. Am J Transplant. 2003 Feb;3(2):148–55.
Foley, David P., et al. “Effect of hepatic artery flow on bile secretory function after cold ischemia.Am J Transplant, vol. 3, no. 2, Feb. 2003, pp. 148–55. Pubmed, doi:10.1034/j.1600-6143.2003.00008.x.
Foley DP, Ricciardi R, Traylor AN, McLaughlin TJ, Donohue SE, Wheeler SM, Meyers WC, Quarfordt SH. Effect of hepatic artery flow on bile secretory function after cold ischemia. Am J Transplant. 2003 Feb;3(2):148–155.
Journal cover image

Published In

Am J Transplant

DOI

ISSN

1600-6135

Publication Date

February 2003

Volume

3

Issue

2

Start / End Page

148 / 155

Location

United States

Related Subject Headings

  • Tissue Survival
  • Taurocholic Acid
  • Swine
  • Surgery
  • Reperfusion Injury
  • Liver Transplantation
  • Liver
  • Ischemia
  • Hepatic Artery
  • Female