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Effect of alternate day fasting on markers of bone metabolism: An exploratory analysis of a 6-month randomized controlled trial.

Publication ,  Journal Article
Barnosky, A; Kroeger, CM; Trepanowski, JF; Klempel, MC; Bhutani, S; Hoddy, KK; Gabel, K; Shapses, SA; Varady, KA
Published in: Nutr Healthy Aging
December 7, 2017

BACKGROUND: Alternate day fasting (ADF) is a novel diet therapy that reduces body weight, but its effect on bone health remains unknown. OBJECTIVE: This study examined the impact of ADF versus traditional daily calorie restriction (CR) on markers of bone metabolism in a 6-month randomized controlled trial. METHODS: Overweight and obese subjects (n = 100) were randomized to 1 of 3 groups for 6 months: 1) ADF (25% energy intake fast day, alternated with 125% intake feast day; 2) CR (75% intake every day); or 3) control (usual intake every day). RESULTS: Body weight decreased similarly (P < 0.001) by ADF (-7.8±1.2%) and CR (-8.8±1.5%), relative to controls by month 6. Lean mass, total body bone mineral content and total body bone mineral density remained unchanged in all groups. Circulating osteocalcin, bone alkaline phosphatase, and C-terminal telopeptide type I collagen (CTX) did not change in any group. IGF-1 increased (P < 0.01) in the CR group, with no change in the ADF or control group. When the data were sub-analyzed according to menopausal status, there were no differences between premenopausal or postmenopausal women for any marker of bone metabolism. CONCLUSION: These findings suggest that 6 months of ADF does not have any deleterious impact on markers of bone metabolism in obese adults with moderate weight loss.

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Published In

Nutr Healthy Aging

DOI

ISSN

2451-9480

Publication Date

December 7, 2017

Volume

4

Issue

3

Start / End Page

255 / 263

Location

Netherlands
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Barnosky, A., Kroeger, C. M., Trepanowski, J. F., Klempel, M. C., Bhutani, S., Hoddy, K. K., … Varady, K. A. (2017). Effect of alternate day fasting on markers of bone metabolism: An exploratory analysis of a 6-month randomized controlled trial. Nutr Healthy Aging, 4(3), 255–263. https://doi.org/10.3233/NHA-170031
Barnosky, Adrienne, Cynthia M. Kroeger, John F. Trepanowski, Monica C. Klempel, Surabhi Bhutani, Kristin K. Hoddy, Kelsey Gabel, Sue A. Shapses, and Krista A. Varady. “Effect of alternate day fasting on markers of bone metabolism: An exploratory analysis of a 6-month randomized controlled trial.Nutr Healthy Aging 4, no. 3 (December 7, 2017): 255–63. https://doi.org/10.3233/NHA-170031.
Barnosky A, Kroeger CM, Trepanowski JF, Klempel MC, Bhutani S, Hoddy KK, et al. Effect of alternate day fasting on markers of bone metabolism: An exploratory analysis of a 6-month randomized controlled trial. Nutr Healthy Aging. 2017 Dec 7;4(3):255–63.
Barnosky, Adrienne, et al. “Effect of alternate day fasting on markers of bone metabolism: An exploratory analysis of a 6-month randomized controlled trial.Nutr Healthy Aging, vol. 4, no. 3, Dec. 2017, pp. 255–63. Pubmed, doi:10.3233/NHA-170031.
Barnosky A, Kroeger CM, Trepanowski JF, Klempel MC, Bhutani S, Hoddy KK, Gabel K, Shapses SA, Varady KA. Effect of alternate day fasting on markers of bone metabolism: An exploratory analysis of a 6-month randomized controlled trial. Nutr Healthy Aging. 2017 Dec 7;4(3):255–263.

Published In

Nutr Healthy Aging

DOI

ISSN

2451-9480

Publication Date

December 7, 2017

Volume

4

Issue

3

Start / End Page

255 / 263

Location

Netherlands