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Vintage treatments for PTSD: a reconsideration of tricyclic drugs.

Publication ,  Journal Article
Davidson, J
Published in: J Psychopharmacol
March 2015

Serotonin (SSRI) and serotonin-norepinephrine (SNRI) reuptake inhibitors (SSRI) are the first-line recommended drug treatments for post-traumatic stress disorder (PTSD); but despite their benefits, much residual pathology remains and no new drugs have yet emerged with a clearly demonstrated benefit for treating the disorder. A case is made that tricyclic drugs deserve a closer look, based on their ability to affect several of the main neurotransmitters that are relevant to PTSD. Their promising efficacy, which was shown 30 years ago, had not been followed up, until a recent trial of desipramine found advantages over a SSRI in PTSD with comorbid alcohol dependence. Opportunities exist for studying newer and purportedly safer tricyclic formulations, as well as further the work with older, established compounds. A reappraisal of their risk:benefit ratio seems in order, when treating PTSD.

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Published In

J Psychopharmacol

DOI

EISSN

1461-7285

Publication Date

March 2015

Volume

29

Issue

3

Start / End Page

264 / 269

Location

United States

Related Subject Headings

  • Stress Disorders, Post-Traumatic
  • Selective Serotonin Reuptake Inhibitors
  • Psychiatry
  • Humans
  • Diagnosis, Dual (Psychiatry)
  • Desipramine
  • Antidepressive Agents, Tricyclic
  • Alcoholism
  • Adrenergic Uptake Inhibitors
  • 42 Health sciences
 

Citation

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Davidson, J. (2015). Vintage treatments for PTSD: a reconsideration of tricyclic drugs. J Psychopharmacol, 29(3), 264–269. https://doi.org/10.1177/0269881114565143
Davidson, Jonathan. “Vintage treatments for PTSD: a reconsideration of tricyclic drugs.J Psychopharmacol 29, no. 3 (March 2015): 264–69. https://doi.org/10.1177/0269881114565143.
Davidson J. Vintage treatments for PTSD: a reconsideration of tricyclic drugs. J Psychopharmacol. 2015 Mar;29(3):264–9.
Davidson, Jonathan. “Vintage treatments for PTSD: a reconsideration of tricyclic drugs.J Psychopharmacol, vol. 29, no. 3, Mar. 2015, pp. 264–69. Pubmed, doi:10.1177/0269881114565143.
Davidson J. Vintage treatments for PTSD: a reconsideration of tricyclic drugs. J Psychopharmacol. 2015 Mar;29(3):264–269.
Journal cover image

Published In

J Psychopharmacol

DOI

EISSN

1461-7285

Publication Date

March 2015

Volume

29

Issue

3

Start / End Page

264 / 269

Location

United States

Related Subject Headings

  • Stress Disorders, Post-Traumatic
  • Selective Serotonin Reuptake Inhibitors
  • Psychiatry
  • Humans
  • Diagnosis, Dual (Psychiatry)
  • Desipramine
  • Antidepressive Agents, Tricyclic
  • Alcoholism
  • Adrenergic Uptake Inhibitors
  • 42 Health sciences