Scholars@Duke publication: Red blood cell catechol O-methyl transferase and response to imipramine in unipolar depressive women.

Red blood cell catechol O-methyl transferase and response to imipramine in unipolar depressive women.

Publication , Journal Article

Davidson, RT; Mcleod, MN; White, HL; Raft, D

Published in: Am J Psychiatry

August 1976

When baseline red blood cell catechol O-methyltransferase (COMT) was measured in 15 unipolar depressive women, the authors found a linear correlation between COMT and response to imipramine (best outcome occurring at low COMT). The results of this study were not related to such variables as intensity of depression, family history, or psychiatric history. The authors suggest that this assay may be useful either as a predictor of response to the drug or as a guide in choosing the optimum dose.

Duke Scholars

Author Jonathan R.T. Davidson Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychol ...

Published In

Am J Psychiatry

DOI

10.1176/ajp.133.8.952

ISSN

0002-953X

Publication Date

August 1976

Volume

133

Issue

Start / End Page

952 / 955

Location

United States

Related Subject Headings

Psychiatry
Middle Aged
Imipramine
Humans
Female
Erythrocytes
Depression
Catechol O-Methyltransferase
Aged
Adult

Citation

APA

Chicago

ICMJE

MLA

NLM

Davidson, R. T., Mcleod, M. N., White, H. L., & Raft, D. (1976). Red blood cell catechol O-methyl transferase and response to imipramine in unipolar depressive women. Am J Psychiatry, 133(8), 952–955. https://doi.org/10.1176/ajp.133.8.952

Davidson, R. T., M. N. Mcleod, H. L. White, and D. Raft. “Red blood cell catechol O-methyl transferase and response to imipramine in unipolar depressive women.” Am J Psychiatry 133, no. 8 (August 1976): 952–55. https://doi.org/10.1176/ajp.133.8.952.

Davidson RT, Mcleod MN, White HL, Raft D. Red blood cell catechol O-methyl transferase and response to imipramine in unipolar depressive women. Am J Psychiatry. 1976 Aug;133(8):952–5.

Davidson, R. T., et al. “Red blood cell catechol O-methyl transferase and response to imipramine in unipolar depressive women.” Am J Psychiatry, vol. 133, no. 8, Aug. 1976, pp. 952–55. Pubmed, doi:10.1176/ajp.133.8.952.

Davidson RT, Mcleod MN, White HL, Raft D. Red blood cell catechol O-methyl transferase and response to imipramine in unipolar depressive women. Am J Psychiatry. 1976 Aug;133(8):952–955.