Scholars@Duke publication: Inhibition of platelet monoamine oxidase in depressed subjects treated with phenelzine.

Inhibition of platelet monoamine oxidase in depressed subjects treated with phenelzine.

Publication , Journal Article

Davidson, J; McLeod, MN; White, HL

Published in: Am J Psychiatry

April 1978

The authors treated 19 depressive inpatients double-blind with a mean dose of 78 mg/day of phenelzine for 3 weeks to determine the possible relationship between monoamine oxidase (MAO) inhibition and the effectiveness of phenelzine. Clinical ratings made on the Hamilton Depression Rating Scale, the Beck Depression Inventory, and the SCL-90 indicated a minimum of 60% MAO inhibition had to be achieved for the drug to be consistently beneficial.

Duke Scholars

Author Jonathan R.T. Davidson Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychol ...

Published In

Am J Psychiatry

DOI

10.1176/ajp.135.4.470

ISSN

0002-953X

Publication Date

April 1978

Volume

135

Issue

Start / End Page

470 / 472

Location

United States

Related Subject Headings

Psychiatry
Phenelzine
Monoamine Oxidase
Humans
Drug Evaluation
Double-Blind Method
Dose-Response Relationship, Drug
Depression
Clinical Trials as Topic
Blood Platelets

Citation

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ICMJE

MLA

NLM

Davidson, J., McLeod, M. N., & White, H. L. (1978). Inhibition of platelet monoamine oxidase in depressed subjects treated with phenelzine. Am J Psychiatry, 135(4), 470–472. https://doi.org/10.1176/ajp.135.4.470

Davidson, J., M. N. McLeod, and H. L. White. “Inhibition of platelet monoamine oxidase in depressed subjects treated with phenelzine.” Am J Psychiatry 135, no. 4 (April 1978): 470–72. https://doi.org/10.1176/ajp.135.4.470.

Davidson J, McLeod MN, White HL. Inhibition of platelet monoamine oxidase in depressed subjects treated with phenelzine. Am J Psychiatry. 1978 Apr;135(4):470–2.

Davidson, J., et al. “Inhibition of platelet monoamine oxidase in depressed subjects treated with phenelzine.” Am J Psychiatry, vol. 135, no. 4, Apr. 1978, pp. 470–72. Pubmed, doi:10.1176/ajp.135.4.470.

Davidson J, McLeod MN, White HL. Inhibition of platelet monoamine oxidase in depressed subjects treated with phenelzine. Am J Psychiatry. 1978 Apr;135(4):470–472.