MAO inhibition and control of anxiety following amitriptyline therapy. A pilot study.
Publication
, Journal Article
Davidson, J; Linnoila, M; Raft, D; Turnbull, CD
Published in: Acta Psychiatr Scand
February 1981
In a pilot study, 32 patients with mixed states of anxiety, depression, somatization and panic received amitriptyline for 4 weeks, the dose ranging from 50 to 300 mg/day. Steady-state plasma levels of the drug and activity of platelet monoamine oxidase were measured after 4 weeks. Clinical change was rated, using the SCL-90. Amitriptyline produced a small but significant inhibition of platelet monoamine oxidase activity (range 1.4--82%). A significant positive correlation was noted between MAO inhibition and improvement on somatization, and psychological and panic-phobic components of anxiety, but not for depression. No significant correlations were observed between improvement and combined or separate ami- + nortriptyline plasma levels.
Duke Scholars
Published In
Acta Psychiatr Scand
DOI
ISSN
0001-690X
Publication Date
February 1981
Volume
63
Issue
2
Start / End Page
147 / 152
Location
United States
Related Subject Headings
- Psychiatry
- Pilot Projects
- Nortriptyline
- Monoamine Oxidase Inhibitors
- Monoamine Oxidase
- Male
- Humans
- Female
- Blood Platelets
- Anxiety Disorders
Citation
APA
Chicago
ICMJE
MLA
NLM
Davidson, J., Linnoila, M., Raft, D., & Turnbull, C. D. (1981). MAO inhibition and control of anxiety following amitriptyline therapy. A pilot study. Acta Psychiatr Scand, 63(2), 147–152. https://doi.org/10.1111/j.1600-0447.1981.tb00660.x
Davidson, J., M. Linnoila, D. Raft, and C. D. Turnbull. “MAO inhibition and control of anxiety following amitriptyline therapy. A pilot study.” Acta Psychiatr Scand 63, no. 2 (February 1981): 147–52. https://doi.org/10.1111/j.1600-0447.1981.tb00660.x.
Davidson J, Linnoila M, Raft D, Turnbull CD. MAO inhibition and control of anxiety following amitriptyline therapy. A pilot study. Acta Psychiatr Scand. 1981 Feb;63(2):147–52.
Davidson, J., et al. “MAO inhibition and control of anxiety following amitriptyline therapy. A pilot study.” Acta Psychiatr Scand, vol. 63, no. 2, Feb. 1981, pp. 147–52. Pubmed, doi:10.1111/j.1600-0447.1981.tb00660.x.
Davidson J, Linnoila M, Raft D, Turnbull CD. MAO inhibition and control of anxiety following amitriptyline therapy. A pilot study. Acta Psychiatr Scand. 1981 Feb;63(2):147–152.
Published In
Acta Psychiatr Scand
DOI
ISSN
0001-690X
Publication Date
February 1981
Volume
63
Issue
2
Start / End Page
147 / 152
Location
United States
Related Subject Headings
- Psychiatry
- Pilot Projects
- Nortriptyline
- Monoamine Oxidase Inhibitors
- Monoamine Oxidase
- Male
- Humans
- Female
- Blood Platelets
- Anxiety Disorders