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MAO inhibition and control of anxiety following amitriptyline therapy. A pilot study.

Publication ,  Journal Article
Davidson, J; Linnoila, M; Raft, D; Turnbull, CD
Published in: Acta Psychiatr Scand
February 1981

In a pilot study, 32 patients with mixed states of anxiety, depression, somatization and panic received amitriptyline for 4 weeks, the dose ranging from 50 to 300 mg/day. Steady-state plasma levels of the drug and activity of platelet monoamine oxidase were measured after 4 weeks. Clinical change was rated, using the SCL-90. Amitriptyline produced a small but significant inhibition of platelet monoamine oxidase activity (range 1.4--82%). A significant positive correlation was noted between MAO inhibition and improvement on somatization, and psychological and panic-phobic components of anxiety, but not for depression. No significant correlations were observed between improvement and combined or separate ami- + nortriptyline plasma levels.

Duke Scholars

Published In

Acta Psychiatr Scand

DOI

ISSN

0001-690X

Publication Date

February 1981

Volume

63

Issue

2

Start / End Page

147 / 152

Location

United States

Related Subject Headings

  • Psychiatry
  • Pilot Projects
  • Nortriptyline
  • Monoamine Oxidase Inhibitors
  • Monoamine Oxidase
  • Male
  • Humans
  • Female
  • Blood Platelets
  • Anxiety Disorders
 

Citation

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Davidson, J., Linnoila, M., Raft, D., & Turnbull, C. D. (1981). MAO inhibition and control of anxiety following amitriptyline therapy. A pilot study. Acta Psychiatr Scand, 63(2), 147–152. https://doi.org/10.1111/j.1600-0447.1981.tb00660.x
Davidson, J., M. Linnoila, D. Raft, and C. D. Turnbull. “MAO inhibition and control of anxiety following amitriptyline therapy. A pilot study.Acta Psychiatr Scand 63, no. 2 (February 1981): 147–52. https://doi.org/10.1111/j.1600-0447.1981.tb00660.x.
Davidson J, Linnoila M, Raft D, Turnbull CD. MAO inhibition and control of anxiety following amitriptyline therapy. A pilot study. Acta Psychiatr Scand. 1981 Feb;63(2):147–52.
Davidson, J., et al. “MAO inhibition and control of anxiety following amitriptyline therapy. A pilot study.Acta Psychiatr Scand, vol. 63, no. 2, Feb. 1981, pp. 147–52. Pubmed, doi:10.1111/j.1600-0447.1981.tb00660.x.
Davidson J, Linnoila M, Raft D, Turnbull CD. MAO inhibition and control of anxiety following amitriptyline therapy. A pilot study. Acta Psychiatr Scand. 1981 Feb;63(2):147–152.
Journal cover image

Published In

Acta Psychiatr Scand

DOI

ISSN

0001-690X

Publication Date

February 1981

Volume

63

Issue

2

Start / End Page

147 / 152

Location

United States

Related Subject Headings

  • Psychiatry
  • Pilot Projects
  • Nortriptyline
  • Monoamine Oxidase Inhibitors
  • Monoamine Oxidase
  • Male
  • Humans
  • Female
  • Blood Platelets
  • Anxiety Disorders