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Gestational hypertensive disorders and retinal microvasculature: the Generation R Study.

Publication ,  Journal Article
Benschop, L; Schalekamp-Timmermans, S; Roeters van Lennep, JE; Jaddoe, VWV; Wong, TY; Cheung, CY; Steegers, EAP; Ikram, MK
Published in: BMC Med
August 14, 2017

BACKGROUND: Changes in the microvasculature associated with pre-eclampsia and gestational hypertension have been proposed as a potential pathway in the development of cardiovascular disease. We examined whether gestational hypertensive disorders, such as pre-eclampsia and gestational hypertension, are related to the maternal retinal microvasculature status after pregnancy. METHODS: This study is part of an ongoing population-based prospective cohort study. During pregnancy and 6.2 years after the index pregnancy (90% range 5.7-7.4 years), we examined 3391 women with available information on pre-eclampsia, gestational hypertension, and retinal vascular calibers. Retinal arteriolar and venular calibers were measured in the left eye from digitized retinal photographs. RESULTS: Women with pre-eclampsia had smaller retinal arteriolar calibers 6 years after pregnancy than women with a normotensive pregnancy (adjusted difference: -0.40 standard deviation score [SDS]; 95% confidence interval [CI]: -0.62, -0.19). For women with previous gestational hypertension, similar trends were observed (-0.20 SDS; 95% CI: -0.34, -0.05). With respect to retinal venular calibers, we did not observe consistent trends for women with previous pre-eclampsia. However, in women with previous gestational hypertension, we observed larger venular calibers (0.22 SDS; 95% CI: 0.07-0.36) than in women with a previous normotensive pregnancy. The association of gestational hypertensive disorders with retinal vessel calibers was mediated through mean arterial pressure at the time of retinal imaging. CONCLUSIONS: Compared to women with a previous normotensive pregnancy, women with pre-eclampsia and gestational hypertension show an altered status of the microvasculature 6 years after the index pregnancy. This is reflected by smaller retinal arteriolar calibers and wider retinal venular calibers. These microvascular changes may possibly contribute to the development of cardiovascular disease in later life.

Duke Scholars

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Published In

BMC Med

DOI

EISSN

1741-7015

Publication Date

August 14, 2017

Volume

15

Issue

1

Start / End Page

153

Location

England

Related Subject Headings

  • Retinal Vessels
  • Prospective Studies
  • Pregnancy
  • Pre-Eclampsia
  • Microvessels
  • Hypertension, Pregnancy-Induced
  • Humans
  • General & Internal Medicine
  • Female
  • Blood Pressure
 

Citation

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Chicago
ICMJE
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Benschop, L., Schalekamp-Timmermans, S., Roeters van Lennep, J. E., Jaddoe, V. W. V., Wong, T. Y., Cheung, C. Y., … Ikram, M. K. (2017). Gestational hypertensive disorders and retinal microvasculature: the Generation R Study. BMC Med, 15(1), 153. https://doi.org/10.1186/s12916-017-0917-2
Benschop, Laura, Sarah Schalekamp-Timmermans, Jeanine E. Roeters van Lennep, Vincent W. V. Jaddoe, Tien Yin Wong, Carol Y. Cheung, Eric A. P. Steegers, and M Kamran Ikram. “Gestational hypertensive disorders and retinal microvasculature: the Generation R Study.BMC Med 15, no. 1 (August 14, 2017): 153. https://doi.org/10.1186/s12916-017-0917-2.
Benschop L, Schalekamp-Timmermans S, Roeters van Lennep JE, Jaddoe VWV, Wong TY, Cheung CY, et al. Gestational hypertensive disorders and retinal microvasculature: the Generation R Study. BMC Med. 2017 Aug 14;15(1):153.
Benschop, Laura, et al. “Gestational hypertensive disorders and retinal microvasculature: the Generation R Study.BMC Med, vol. 15, no. 1, Aug. 2017, p. 153. Pubmed, doi:10.1186/s12916-017-0917-2.
Benschop L, Schalekamp-Timmermans S, Roeters van Lennep JE, Jaddoe VWV, Wong TY, Cheung CY, Steegers EAP, Ikram MK. Gestational hypertensive disorders and retinal microvasculature: the Generation R Study. BMC Med. 2017 Aug 14;15(1):153.
Journal cover image

Published In

BMC Med

DOI

EISSN

1741-7015

Publication Date

August 14, 2017

Volume

15

Issue

1

Start / End Page

153

Location

England

Related Subject Headings

  • Retinal Vessels
  • Prospective Studies
  • Pregnancy
  • Pre-Eclampsia
  • Microvessels
  • Hypertension, Pregnancy-Induced
  • Humans
  • General & Internal Medicine
  • Female
  • Blood Pressure