Notice of Removal: Spatio-temporal consistency of transthoracic ARFI-derived metrics of myocardial function
Cardiac function has traditionally been studied using pressure-volume (PV) loop analysis. PV loops can be used to derive functional indices such as end-systolic pressure volume relationship (ESPVR) - a measure of myocardial contractility, end-diastolic pressure volume relationship (EDPVR) - a measure of myocardial compliance and relaxation time constant (τ) - a measure of left ventricular relaxation. However, PV loop analysis is largely an invasive proedure; it requires catherization and only provides a global assessment of cardiac function. Transthoracic ARFI (TTE ARFI) has been shown to capture the dynamic trends of myocardial stiffness over the cardiac cycle in a noninvasive manner. In this work we explore the potential of using myocardial stiffness measurements made using TTE ARFI to derive functional indices similar to the ones measured using PV loops. We studied parameters impacting the spatio-temporal stability and reliability of TTE ARFI-derived measures of myocardial function.
