Notice of Removal: Clinical feasibility of a noninvasive method to interrogate myocardial function via strain and acoustic radiation force-derived stiffness
Myocardial elastance, derived from pressure-volume (PV) loops in the left ventricle (LV), can be used to assess LV function and myocardial performance. This method requires an invasive intracardiac pressure-volume catheter to be inserted in the LV, limiting the method's utility in clinical screening and monitoring. Strain echocardiography and cardiac acoustic radiation force impulse (ARFI) imaging are ultrasonic techniques to noninvasively asses myocardial function by tracking the deformation through the cardiac cycle and the tissue response to repeated impulsive acoustic radiation force, respectively. Strain and ARFI imaging have largely been used in separate contexts. Our group has previously demonstrated the use of cardiac ARFI and strain in an invasive open-chest animal study, but this is the first work to examine the relationship between ARFI-derived stiffness and strain in a noninvasive in vivo clinical study.
