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Tunable wavelength interrogated sensor platform (TWIST) for point-of-care diagnostics of infectious diseases

Publication ,  Conference
Grego, S; Gilchrist, KH; Stoner, BR
Published in: Proceedings of SPIE - The International Society for Optical Engineering
July 6, 2011

The TWIST platform is an optical evanescent wave sensor which enables a label-free immunoassay-based portable instrument. The approach is based on input grating coupler sensors serving as functionalized sensing devices. Binding of the target analyte to the receptor-coated grating is detected by wavelength interrogation in the telecom spectral range. We have demonstrated that high performance volumetric sensing can be achieved using a compact, low-cost telecom laser as light source. The system footprint including light source, detectors and digitizers is compact. The platform is amenable to multiplexed operation. We demonstrated a two-output system which enables detection of an analyte with an on-chip reference signal. © 2011 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE).

Duke Scholars

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

ISSN

0277-786X

Publication Date

July 6, 2011

Volume

8029

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
 

Citation

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Grego, S., Gilchrist, K. H., & Stoner, B. R. (2011). Tunable wavelength interrogated sensor platform (TWIST) for point-of-care diagnostics of infectious diseases. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 8029). https://doi.org/10.1117/12.886880
Grego, S., K. H. Gilchrist, and B. R. Stoner. “Tunable wavelength interrogated sensor platform (TWIST) for point-of-care diagnostics of infectious diseases.” In Proceedings of SPIE - The International Society for Optical Engineering, Vol. 8029, 2011. https://doi.org/10.1117/12.886880.
Grego S, Gilchrist KH, Stoner BR. Tunable wavelength interrogated sensor platform (TWIST) for point-of-care diagnostics of infectious diseases. In: Proceedings of SPIE - The International Society for Optical Engineering. 2011.
Grego, S., et al. “Tunable wavelength interrogated sensor platform (TWIST) for point-of-care diagnostics of infectious diseases.” Proceedings of SPIE - The International Society for Optical Engineering, vol. 8029, 2011. Scopus, doi:10.1117/12.886880.
Grego S, Gilchrist KH, Stoner BR. Tunable wavelength interrogated sensor platform (TWIST) for point-of-care diagnostics of infectious diseases. Proceedings of SPIE - The International Society for Optical Engineering. 2011.

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

ISSN

0277-786X

Publication Date

July 6, 2011

Volume

8029

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering