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A compact and multichannel optical biosensor based on a wavelength interrogated input grating coupler

Publication ,  Journal Article
Grego, S; Gilchrist, KH; Carlson, JB; Stoner, BR
Published in: Sensors and Actuators, B: Chemical
January 3, 2012

The design, fabrication and characterization of a compact optical biosensor based on an input grating coupler are presented. The sensor device consists of a waveguide-integrated single grating structure. The optical reader is based on the use of a largely tunable, small footprint infrared laser for wavelength interrogation of the sensor and on edge-detection of waveguided modes, resulting in a compact configuration. A multiplexing approach is illustrated and a two-output sensor system is demonstrated. The device is packaged in a microfluidic cartridge for sample handling. The volumetric sensing performance of the system is characterized and a limit of detection of 1 × 10 -5 RIU is reported while the surface sensing capability is demonstrated by detection of protein diluted down to 200 ng/ml. © 2011 Elsevier B.V. All rights reserved.

Duke Scholars

Published In

Sensors and Actuators, B: Chemical

DOI

ISSN

0925-4005

Publication Date

January 3, 2012

Volume

161

Issue

1

Start / End Page

721 / 727

Related Subject Headings

  • Analytical Chemistry
  • 4016 Materials engineering
  • 4004 Chemical engineering
  • 3401 Analytical chemistry
  • 0912 Materials Engineering
  • 0301 Analytical Chemistry
  • 0205 Optical Physics
 

Citation

APA
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ICMJE
MLA
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Grego, S., Gilchrist, K. H., Carlson, J. B., & Stoner, B. R. (2012). A compact and multichannel optical biosensor based on a wavelength interrogated input grating coupler. Sensors and Actuators, B: Chemical, 161(1), 721–727. https://doi.org/10.1016/j.snb.2011.11.020
Grego, S., K. H. Gilchrist, J. B. Carlson, and B. R. Stoner. “A compact and multichannel optical biosensor based on a wavelength interrogated input grating coupler.” Sensors and Actuators, B: Chemical 161, no. 1 (January 3, 2012): 721–27. https://doi.org/10.1016/j.snb.2011.11.020.
Grego S, Gilchrist KH, Carlson JB, Stoner BR. A compact and multichannel optical biosensor based on a wavelength interrogated input grating coupler. Sensors and Actuators, B: Chemical. 2012 Jan 3;161(1):721–7.
Grego, S., et al. “A compact and multichannel optical biosensor based on a wavelength interrogated input grating coupler.” Sensors and Actuators, B: Chemical, vol. 161, no. 1, Jan. 2012, pp. 721–27. Scopus, doi:10.1016/j.snb.2011.11.020.
Grego S, Gilchrist KH, Carlson JB, Stoner BR. A compact and multichannel optical biosensor based on a wavelength interrogated input grating coupler. Sensors and Actuators, B: Chemical. 2012 Jan 3;161(1):721–727.
Journal cover image

Published In

Sensors and Actuators, B: Chemical

DOI

ISSN

0925-4005

Publication Date

January 3, 2012

Volume

161

Issue

1

Start / End Page

721 / 727

Related Subject Headings

  • Analytical Chemistry
  • 4016 Materials engineering
  • 4004 Chemical engineering
  • 3401 Analytical chemistry
  • 0912 Materials Engineering
  • 0301 Analytical Chemistry
  • 0205 Optical Physics