A compact and multichannel optical biosensor based on a wavelength interrogated input grating coupler
The design, fabrication and characterization of a compact optical biosensor based on an input grating coupler are presented. The sensor device consists of a waveguide-integrated single grating structure. The optical reader is based on the use of a largely tunable, small footprint infrared laser for wavelength interrogation of the sensor and on edge-detection of waveguided modes, resulting in a compact configuration. A multiplexing approach is illustrated and a two-output sensor system is demonstrated. The device is packaged in a microfluidic cartridge for sample handling. The volumetric sensing performance of the system is characterized and a limit of detection of 1 × 10 -5 RIU is reported while the surface sensing capability is demonstrated by detection of protein diluted down to 200 ng/ml. © 2011 Elsevier B.V. All rights reserved.
Duke Scholars
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Related Subject Headings
- Analytical Chemistry
- 4016 Materials engineering
- 4004 Chemical engineering
- 3401 Analytical chemistry
- 0912 Materials Engineering
- 0301 Analytical Chemistry
- 0205 Optical Physics
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Analytical Chemistry
- 4016 Materials engineering
- 4004 Chemical engineering
- 3401 Analytical chemistry
- 0912 Materials Engineering
- 0301 Analytical Chemistry
- 0205 Optical Physics