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Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization.

Publication ,  Journal Article
Sewell, D; Qing, Z; Reinke, E; Elliot, D; Weinstock, J; Sandor, M; Fabry, Z
Published in: International immunology
January 2003

Experimental autoimmune encephalomyelitis (EAE) is an animal model for multiple sclerosis (MS) characterized by chronic inflammatory demyelination of the central nervous system (CNS). The pathology of EAE involves autoimmune CD4(+) T(h)1 cells. There is a striking inverse correlation between the occurrence of parasitic and autoimmune diseases. We demonstrate that in mice with Schistosoma mansoni ova immunization, the severity of EAE is reduced as measured by decreased clinical scores and CNS cellular infiltrates. Disease suppression is associated with immune deviation in the periphery and the CNS, demonstrated by decreased IFN-gamma and increased IL-4, transforming growth factor-beta and IL-10 levels in the periphery, and increased frequency of IL-4 producing neuroantigen-specific T cells in the brain. S. mansoni helminth ova treatment influenced the course of EAE in wild-type mice, but not in STAT6-deficient animals. This indicates that STAT6 plays a critical role in regulating the ameliorating effect of S. mansoni ova treatment on the autoimmune response, and provides the direct link between helminth treatment, T(h)2 environment and improved EAE. As some intestinal helminthic infections induce minimal pathology, they might offer a safe and inexpensive therapy to prevent and/or ameliorate MS.

Duke Scholars

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Published In

International immunology

DOI

EISSN

1460-2377

ISSN

0953-8178

Publication Date

January 2003

Volume

15

Issue

1

Start / End Page

59 / 69

Related Subject Headings

  • Trans-Activators
  • STAT6 Transcription Factor
  • Ovalbumin
  • Multiple Sclerosis
  • Models, Animal
  • Mice, Inbred C57BL
  • Mice
  • Lymphocyte Activation
  • Interleukin-4
  • Immunology
 

Citation

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ICMJE
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Sewell, D., Qing, Z., Reinke, E., Elliot, D., Weinstock, J., Sandor, M., & Fabry, Z. (2003). Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization. International Immunology, 15(1), 59–69. https://doi.org/10.1093/intimm/dxg012
Sewell, Diane, Zhu Qing, Emily Reinke, David Elliot, Joel Weinstock, Matyas Sandor, and Zsuzsa Fabry. “Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization.International Immunology 15, no. 1 (January 2003): 59–69. https://doi.org/10.1093/intimm/dxg012.
Sewell D, Qing Z, Reinke E, Elliot D, Weinstock J, Sandor M, et al. Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization. International immunology. 2003 Jan;15(1):59–69.
Sewell, Diane, et al. “Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization.International Immunology, vol. 15, no. 1, Jan. 2003, pp. 59–69. Epmc, doi:10.1093/intimm/dxg012.
Sewell D, Qing Z, Reinke E, Elliot D, Weinstock J, Sandor M, Fabry Z. Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization. International immunology. 2003 Jan;15(1):59–69.
Journal cover image

Published In

International immunology

DOI

EISSN

1460-2377

ISSN

0953-8178

Publication Date

January 2003

Volume

15

Issue

1

Start / End Page

59 / 69

Related Subject Headings

  • Trans-Activators
  • STAT6 Transcription Factor
  • Ovalbumin
  • Multiple Sclerosis
  • Models, Animal
  • Mice, Inbred C57BL
  • Mice
  • Lymphocyte Activation
  • Interleukin-4
  • Immunology