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Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections.

Publication ,  Conference
Sewell, DL; Reinke, EK; Hogan, LH; Sandor, M; Fabry, Z
Published in: Immunology letters
June 2002

The 'hygiene hypothesis' has been proposed to explain apparent increases in autoimmune disease and allergy in areas of the world with improved health care and sanitation. This hypothesis proposes that the lack of serious childhood infections impairs development of an appropriately educated immune response. Imbalance of Th1 and Th2 responses and lack of regulatory T-cell populations are two of many proposed potential mechanisms for immune failures such as autoimmunity and allergy. We summarize the literature evidence for the influence of infectious organisms on autoimmunity with focus on helminth and mycobacterial infections. We also demonstrate that Schistosoma mansoni ova pretreatment, Mycobacterium bovis (BCG) infection, and lyophilized Mycobacterium tuberculosis all modify the course of clinical disease in mice induced for experimental autoimmune encephalomyelitis (a mouse model for human multiple sclerosis (MS)). Our data supports the applicability of the hygiene hypothesis to CNS autoimmune disease.

Duke Scholars

Published In

Immunology letters

DOI

EISSN

1879-0542

ISSN

0165-2478

Publication Date

June 2002

Volume

82

Issue

1-2

Start / End Page

101 / 110

Related Subject Headings

  • Th2 Cells
  • Th1 Cells
  • Schistosomiasis mansoni
  • Risk Factors
  • Mycobacterium Infections
  • Models, Immunological
  • Mice
  • Immunology
  • Humans
  • Helminthiasis
 

Citation

APA
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ICMJE
MLA
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Sewell, D. L., Reinke, E. K., Hogan, L. H., Sandor, M., & Fabry, Z. (2002). Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections. In Immunology letters (Vol. 82, pp. 101–110). https://doi.org/10.1016/s0165-2478(02)00025-1
Sewell, Diane L., Emily K. Reinke, Laura H. Hogan, Matyas Sandor, and Zsuzsa Fabry. “Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections.” In Immunology Letters, 82:101–10, 2002. https://doi.org/10.1016/s0165-2478(02)00025-1.
Sewell DL, Reinke EK, Hogan LH, Sandor M, Fabry Z. Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections. In: Immunology letters. 2002. p. 101–10.
Sewell, Diane L., et al. “Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections.Immunology Letters, vol. 82, no. 1–2, 2002, pp. 101–10. Epmc, doi:10.1016/s0165-2478(02)00025-1.
Sewell DL, Reinke EK, Hogan LH, Sandor M, Fabry Z. Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections. Immunology letters. 2002. p. 101–110.
Journal cover image

Published In

Immunology letters

DOI

EISSN

1879-0542

ISSN

0165-2478

Publication Date

June 2002

Volume

82

Issue

1-2

Start / End Page

101 / 110

Related Subject Headings

  • Th2 Cells
  • Th1 Cells
  • Schistosomiasis mansoni
  • Risk Factors
  • Mycobacterium Infections
  • Models, Immunological
  • Mice
  • Immunology
  • Humans
  • Helminthiasis