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Comparison of retinal vascular geometry in obese and non-obese children.

Publication ,  Journal Article
Tai, ELM; Kueh, YC; Wan Hitam, W-H; Wong, TY; Shatriah, I
Published in: PLoS One
2018

PURPOSE: Childhood obesity is associated with adult cardiometabolic disease. We postulate that the underlying microvascular dysfunction begins in childhood. We thus aimed to compare retinal vascular parameters between obese and non-obese children. METHODS: This was a cross-sectional study involving 166 children aged 6 to 12 years old in Malaysia. Ocular examination, biometry, retinal photography, blood pressure and body mass index measurement were performed. Participants were divided into two groups; obese and non-obese. Retinal vascular parameters were measured using validated software. RESULTS: Mean age was 9.58 years. Approximately 51.2% were obese. Obese children had significantly narrower retinal arteriolar caliber (F(1,159) = 6.862, p = 0.010), lower arteriovenous ratio (F(1,159) = 17.412, p < 0.001), higher venular fractal dimension (F(1,159) = 4.313, p = 0.039) and higher venular curvature tortuosity (F(1,158) = 5.166, p = 0.024) than non-obese children, after adjustment for age, gender, blood pressure and axial length. CONCLUSIONS: Obese children have abnormal retinal vascular geometry. These findings suggest that childhood obesity is characterized by early microvascular abnormalities that precede development of overt disease. Further research is warranted to determine if these parameters represent viable biomarkers for risk stratification in obesity.

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Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2018

Volume

13

Issue

2

Start / End Page

e0191434

Location

United States

Related Subject Headings

  • Retinal Vessels
  • Prospective Studies
  • Obesity
  • Male
  • Humans
  • General Science & Technology
  • Female
  • Cross-Sectional Studies
  • Child
  • Case-Control Studies
 

Citation

APA
Chicago
ICMJE
MLA
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Tai, E. L. M., Kueh, Y. C., Wan Hitam, W.-H., Wong, T. Y., & Shatriah, I. (2018). Comparison of retinal vascular geometry in obese and non-obese children. PLoS One, 13(2), e0191434. https://doi.org/10.1371/journal.pone.0191434
Tai, Evelyn Li Min, Yee Cheng Kueh, Wan-Hazabbah Wan Hitam, Tien Yin Wong, and Ismail Shatriah. “Comparison of retinal vascular geometry in obese and non-obese children.PLoS One 13, no. 2 (2018): e0191434. https://doi.org/10.1371/journal.pone.0191434.
Tai ELM, Kueh YC, Wan Hitam W-H, Wong TY, Shatriah I. Comparison of retinal vascular geometry in obese and non-obese children. PLoS One. 2018;13(2):e0191434.
Tai, Evelyn Li Min, et al. “Comparison of retinal vascular geometry in obese and non-obese children.PLoS One, vol. 13, no. 2, 2018, p. e0191434. Pubmed, doi:10.1371/journal.pone.0191434.
Tai ELM, Kueh YC, Wan Hitam W-H, Wong TY, Shatriah I. Comparison of retinal vascular geometry in obese and non-obese children. PLoS One. 2018;13(2):e0191434.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2018

Volume

13

Issue

2

Start / End Page

e0191434

Location

United States

Related Subject Headings

  • Retinal Vessels
  • Prospective Studies
  • Obesity
  • Male
  • Humans
  • General Science & Technology
  • Female
  • Cross-Sectional Studies
  • Child
  • Case-Control Studies