Skip to main content
Journal cover image

Preoperative factors associated with worsening in health-related quality of life following coronary artery bypass grafting in the Randomized On/Off Bypass (ROOBY) trial.

Publication ,  Journal Article
Bishawi, M; Hattler, B; Almassi, GH; Spertus, JA; Quin, JA; Collins, JF; Grover, FL; Shroyer, AL; VA #517 Randomized On/Off Bypass (ROOBY) Study Group
Published in: American heart journal
April 2018

For advanced coronary disease, coronary artery bypass graft (CABG) surgery generally improves patients' symptoms and long-term survival. Unfortunately, some patients experience worse health-related quality of life (HRQL) after CABG. The objective of this study is to report the frequency and risk factors associated with 1-year post-CABG HRQL deterioration.From 2002 to 2007, 2203 "Randomized On/Off Bypass" (ROOBY) trial patients randomly received either off-pump or on-pump CABG at 18 VA medical centers. Subjects completed both baseline and 1-year Seattle Angina Questionnaire (SAQ) and the Veterans Rand 36 (VR-36) questionnaires to assess HRQL. Using previously published criteria, the rates of clinically significant changes were determined for the SAQ [angina frequency (AF), physical limitation (PL), and quality of life (QoL)] and VR36 [mental component score (MCS) and physical component score (PCS)] subscales. Multivariate regression models were then used to identify pre-CABG patient characteristics associated with worsened 1-year HRQL status for each subscale.Over 80% of patients had an improvement or no change in SAQ and VR-36 subscale scores 1 year after CABG. The HRQL scale-specific deterioration rates were 4.5% SAQ-AF, 16.8% SAQ-PL, 4.9% SAQ-QoL, 19.4% VR36-MCS, and 13.5% VR36-PCS. Predictors of 1-year HRQL deterioration were diabetes and smoking for the SAQ-AF; diabetes, chronic obstructive pulmonary disease (COPD), and peripheral vascular disease (PVD) for SAQ-PL; COPD and depression for the SAQ-QoL; diabetes for VR36-PCS, and history of stroke and depression for VR36-MCS. The baseline score was an independent predictor for worsening in all the subscales studied.Among VA patients, less than 20% experienced worse HRQL 1 year after CABG. For patients with low symptom burden at baseline, diabetes, smoking, depression, PVD, COPD, and a prior stroke, clinicians should be more cautious in pre-CABG counseling as to their anticipated HRQL improvements.

Altmetric Attention Stats
Dimensions Citation Stats

Published In

American heart journal

DOI

EISSN

1097-6744

ISSN

0002-8703

Publication Date

April 2018

Volume

198

Start / End Page

33 / 38

Related Subject Headings

  • United States
  • Treatment Outcome
  • Survival Analysis
  • Statistics, Nonparametric
  • Risk Assessment
  • Retrospective Studies
  • Quality of Life
  • Prognosis
  • Preoperative Care
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bishawi, M., Hattler, B., Almassi, G. H., Spertus, J. A., Quin, J. A., Collins, J. F., … VA #517 Randomized On/Off Bypass (ROOBY) Study Group. (2018). Preoperative factors associated with worsening in health-related quality of life following coronary artery bypass grafting in the Randomized On/Off Bypass (ROOBY) trial. American Heart Journal, 198, 33–38. https://doi.org/10.1016/j.ahj.2017.12.014
Bishawi, Muath, Brack Hattler, G Hossein Almassi, John A. Spertus, Jacquelyn A. Quin, Joseph F. Collins, Frederick L. Grover, Annie Laurie Shroyer, and VA #517 Randomized On/Off Bypass (ROOBY) Study Group. “Preoperative factors associated with worsening in health-related quality of life following coronary artery bypass grafting in the Randomized On/Off Bypass (ROOBY) trial.American Heart Journal 198 (April 2018): 33–38. https://doi.org/10.1016/j.ahj.2017.12.014.
Bishawi M, Hattler B, Almassi GH, Spertus JA, Quin JA, Collins JF, et al. Preoperative factors associated with worsening in health-related quality of life following coronary artery bypass grafting in the Randomized On/Off Bypass (ROOBY) trial. American heart journal. 2018 Apr;198:33–8.
Bishawi, Muath, et al. “Preoperative factors associated with worsening in health-related quality of life following coronary artery bypass grafting in the Randomized On/Off Bypass (ROOBY) trial.American Heart Journal, vol. 198, Apr. 2018, pp. 33–38. Epmc, doi:10.1016/j.ahj.2017.12.014.
Bishawi M, Hattler B, Almassi GH, Spertus JA, Quin JA, Collins JF, Grover FL, Shroyer AL, VA #517 Randomized On/Off Bypass (ROOBY) Study Group. Preoperative factors associated with worsening in health-related quality of life following coronary artery bypass grafting in the Randomized On/Off Bypass (ROOBY) trial. American heart journal. 2018 Apr;198:33–38.
Journal cover image

Published In

American heart journal

DOI

EISSN

1097-6744

ISSN

0002-8703

Publication Date

April 2018

Volume

198

Start / End Page

33 / 38

Related Subject Headings

  • United States
  • Treatment Outcome
  • Survival Analysis
  • Statistics, Nonparametric
  • Risk Assessment
  • Retrospective Studies
  • Quality of Life
  • Prognosis
  • Preoperative Care
  • Middle Aged