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Uninvolved skin from psoriatic patients develops signs of involved psoriatic skin after being grafted onto nude mice.

Publication ,  Journal Article
Fraki, JE; Briggaman, RA; Lazarus, GS
Published in: Science
February 5, 1982

Clinically involved psoriatic epidermis maintains its histological appearance, increased labeling index, and increased level of plasminogen activator after being grafted onto athymic nude mice. Uninvolved psoriatic epidermis develops increases in plasminogen activator activity after being grafted onto athymic nude mice; this is accompanied by an increased labeling index. Thus, psoriatic skin can develop markers of psoriasis independent of the host.

Duke Scholars

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

February 5, 1982

Volume

215

Issue

4533

Start / End Page

685 / 687

Location

United States

Related Subject Headings

  • Skin Transplantation
  • Skin
  • Psoriasis
  • Plasminogen Activators
  • Mice, Nude
  • Mice
  • Humans
  • General Science & Technology
  • Disease Models, Animal
  • Cell Division
 

Citation

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ICMJE
MLA
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Fraki, J. E., Briggaman, R. A., & Lazarus, G. S. (1982). Uninvolved skin from psoriatic patients develops signs of involved psoriatic skin after being grafted onto nude mice. Science, 215(4533), 685–687. https://doi.org/10.1126/science.7036342
Fraki, J. E., R. A. Briggaman, and G. S. Lazarus. “Uninvolved skin from psoriatic patients develops signs of involved psoriatic skin after being grafted onto nude mice.Science 215, no. 4533 (February 5, 1982): 685–87. https://doi.org/10.1126/science.7036342.
Fraki, J. E., et al. “Uninvolved skin from psoriatic patients develops signs of involved psoriatic skin after being grafted onto nude mice.Science, vol. 215, no. 4533, Feb. 1982, pp. 685–87. Pubmed, doi:10.1126/science.7036342.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

February 5, 1982

Volume

215

Issue

4533

Start / End Page

685 / 687

Location

United States

Related Subject Headings

  • Skin Transplantation
  • Skin
  • Psoriasis
  • Plasminogen Activators
  • Mice, Nude
  • Mice
  • Humans
  • General Science & Technology
  • Disease Models, Animal
  • Cell Division