Skip to main content
Journal cover image
Immunology: Immunotoxicology, Immunopathology, and Immunotherapy

The Role of Macroautophagy in T Cells

Publication ,  Chapter
Jia, W; McLeod, I; He, MX; He, YW
January 1, 2018

The highly conserved self-digestion pathway macroautophagy (hereafter referred to as autophagy) maintains the homeostasis of organelles, degrades long-lived proteins, and recycles amino acids under starvation conditions. Autophagy related molecules are expressed in T lymphocytes, and autophagy occurs inside T lymphocytes. Autophagy-deficient T lymphocytes, which are generated through the deletion of autophagy related molecules, show expansion of organelles content, increased cell death mediated by apoptosis, proliferation defects, instability of the Treg cell lineage, and defect of memory T cell formation. Several different mouse genetic deficiency models show very similar phenotypes. Thus, autophagy plays multiple roles in the regulation of the physiological functions of T lymphocytes. However, how TCR signaling contributes to the initiation of autophagy in T cells and how T cell functions will be affected if autophagy is modified still need to be further investigated.

Duke Scholars

DOI

ISBN

9780128098196

Publication Date

January 1, 2018

Volume

1

Start / End Page

23 / 33
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Jia, W., McLeod, I., He, M. X., & He, Y. W. (2018). The Role of Macroautophagy in T Cells. In Immunology: Immunotoxicology, Immunopathology, and Immunotherapy (Vol. 1, pp. 23–33). https://doi.org/10.1016/B978-0-12-809819-6.00003-4
Jia, W., I. McLeod, M. X. He, and Y. W. He. “The Role of Macroautophagy in T Cells.” In Immunology: Immunotoxicology, Immunopathology, and Immunotherapy, 1:23–33, 2018. https://doi.org/10.1016/B978-0-12-809819-6.00003-4.
Jia W, McLeod I, He MX, He YW. The Role of Macroautophagy in T Cells. In: Immunology: Immunotoxicology, Immunopathology, and Immunotherapy. 2018. p. 23–33.
Jia, W., et al. “The Role of Macroautophagy in T Cells.” Immunology: Immunotoxicology, Immunopathology, and Immunotherapy, vol. 1, 2018, pp. 23–33. Scopus, doi:10.1016/B978-0-12-809819-6.00003-4.
Jia W, McLeod I, He MX, He YW. The Role of Macroautophagy in T Cells. Immunology: Immunotoxicology, Immunopathology, and Immunotherapy. 2018. p. 23–33.
Journal cover image

DOI

ISBN

9780128098196

Publication Date

January 1, 2018

Volume

1

Start / End Page

23 / 33