Skip to main content

RELATIONSHIP OF CLINICAL FEATURES AND BASELINE TUMOR SIZE WITH GENE EXPRESSION PROFILE STATUS IN UVEAL MELANOMA: A Multi-institutional Study.

Publication ,  Journal Article
Berry, D; Seider, M; Stinnett, S; Mruthyunjaya, P; Schefler, AC; Ocular Oncology Study Consortium,
Published in: Retina
June 2019

PURPOSE: To study the relationship between gene expression profile subclass and clinical features in a multicenter cohort of patients with uveal melanoma. METHODS: A retrospective, multicenter study was undertaken with patients entered from nine major ocular oncology centers from across the United States. Eligible patients had uveal melanoma and underwent I-125 plaque brachytherapy with concurrent tumor biopsy with gene expression profile testing between January 1, 2010, and October 28, 2014. Data were collected regarding patient demographics, baseline tumor clinical features, and gene expression profile results. Statistical analyses were performed using the Fisher's exact test, Wilcoxon rank-sum test, Kruskal-Wallis test, and proportional-odds cumulative logit modeling. RESULTS: Inclusion criteria were met for 379 patients. Gene expression profile class divided the cohort into two main groups, Class 1 (n = 263) and Class 2 (n = 113). Class 1 tumors were further subdivided into Class 1a (n = 186) and Class 1b (n = 77). The differences between Class 1 and Class 2 tumors were similar to previous studies, except the finding of Class 2 tumors being more likely to have associated exudative retinal detachment (P < 0.001). There was no statistically significant difference between Class 1 and Class 2 tumors based on the presence of lipofuscin, drusen, or subretinal fluid. Class 1a tumor patients, compared with Class 1b, were significantly older (P = 0.034). Class 2 tumors, when compared with Class 1b, were associated with increasing patient age (P < 0.001), larger tumor height (P = 0.010), ciliary body involvement (P = 0.001), exudative retinal detachment (P = 0.024), and anterior tumor location (P < 0.001). When the tumors were grouped into Collaborative Ocular Melanoma Study size categories, increasing tumor size category was significantly associated with Class 2 status: 6% of small tumors, 32% of medium tumors, and 53% of large tumors were Class 2. CONCLUSION: In a multi-institutional setting, we found that the only significant difference in clinical features between Class 1a and Class 1b tumors was that patients with Class 1a tumors were older at the time of diagnosis. We also found that Class 1a and Class 1b have clinical features distinct from Class 2 tumors. The distribution of the gene expression profile subclasses among the size groups was similar to reported time-to-metastasis data among the same size groupings. Our clinical findings support the current molecular classification-based survival data previously reported in uveal melanoma.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Retina

DOI

EISSN

1539-2864

Publication Date

June 2019

Volume

39

Issue

6

Start / End Page

1154 / 1164

Location

United States

Related Subject Headings

  • Young Adult
  • Uveal Neoplasms
  • Ultrasonography
  • Retrospective Studies
  • Ophthalmology & Optometry
  • Neoplasm Staging
  • Middle Aged
  • Melanoma
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Berry, D., Seider, M., Stinnett, S., Mruthyunjaya, P., Schefler, A. C., & Ocular Oncology Study Consortium, . (2019). RELATIONSHIP OF CLINICAL FEATURES AND BASELINE TUMOR SIZE WITH GENE EXPRESSION PROFILE STATUS IN UVEAL MELANOMA: A Multi-institutional Study. Retina, 39(6), 1154–1164. https://doi.org/10.1097/IAE.0000000000002113
Berry, Duncan, Michael Seider, Sandra Stinnett, Prithvi Mruthyunjaya, Amy C. Schefler, and Amy C. Ocular Oncology Study Consortium. “RELATIONSHIP OF CLINICAL FEATURES AND BASELINE TUMOR SIZE WITH GENE EXPRESSION PROFILE STATUS IN UVEAL MELANOMA: A Multi-institutional Study.Retina 39, no. 6 (June 2019): 1154–64. https://doi.org/10.1097/IAE.0000000000002113.
Berry D, Seider M, Stinnett S, Mruthyunjaya P, Schefler AC, Ocular Oncology Study Consortium. RELATIONSHIP OF CLINICAL FEATURES AND BASELINE TUMOR SIZE WITH GENE EXPRESSION PROFILE STATUS IN UVEAL MELANOMA: A Multi-institutional Study. Retina. 2019 Jun;39(6):1154–64.
Berry, Duncan, et al. “RELATIONSHIP OF CLINICAL FEATURES AND BASELINE TUMOR SIZE WITH GENE EXPRESSION PROFILE STATUS IN UVEAL MELANOMA: A Multi-institutional Study.Retina, vol. 39, no. 6, June 2019, pp. 1154–64. Pubmed, doi:10.1097/IAE.0000000000002113.
Berry D, Seider M, Stinnett S, Mruthyunjaya P, Schefler AC, Ocular Oncology Study Consortium. RELATIONSHIP OF CLINICAL FEATURES AND BASELINE TUMOR SIZE WITH GENE EXPRESSION PROFILE STATUS IN UVEAL MELANOMA: A Multi-institutional Study. Retina. 2019 Jun;39(6):1154–1164.

Published In

Retina

DOI

EISSN

1539-2864

Publication Date

June 2019

Volume

39

Issue

6

Start / End Page

1154 / 1164

Location

United States

Related Subject Headings

  • Young Adult
  • Uveal Neoplasms
  • Ultrasonography
  • Retrospective Studies
  • Ophthalmology & Optometry
  • Neoplasm Staging
  • Middle Aged
  • Melanoma
  • Male
  • Humans